Method for enhancing bone density or formation
AssigneeGenVec, Inc.
InventorImre Kovesdi
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Abstract
The invention pertains to a method for enhancing bone density or formation. In accordance with the method, a nucleic acid encoding a secreted alkaline phosphatase (SEAP) is administered to a cell in a region of a bone such that the nucleic acid is expressed to produce the SEAP, whereby bone density or formation is enhanced within the region. The method can be employed to produce a bone graft having a cell harboring an exogenous nucleic acid encoding a SEAP. To facilitate the inventive method, the invention provides a recombinant viral vector having a nucleic acid encoding a SEAP. Optionally, a nucleic acid encoding an angiogenic protein and/or a nucleic acid encoding an osteogenic protein is employed in conjunction with the nucleic acid encoding a SEAP.
Claims30
A method for enhancing bone density or formation, the method comprising administering to at least one first cell associated with a region of a bone a first nucleic acid encoding a secreted alkaline phosphatase (SEAP), such that the first nucleic acid is expressed in the cell to produce the SEAP, whereby bone density or formation is enhanced within the region.
A viral vector comprising at least one first nucleic acid encoding a SEAP.
A bone graft comprising a first cell having a first exogenous nucleic acid encoding a SEAP.
A recombinant expression cassette encoding a fusion protein having a first SEAP domain and a second angiogenic or osteogenic domain.
Dependencies are inferred from the claim text.