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US 2003/0158122 A1Published application
Charged lipid compositions and methods for their use
AssigneeOttawa Heart Institute Research Corporation
InventorDaniel L. Sparks
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AssigneeOttawa Heart Institute Research Corporation
InventorDaniel L. Sparks
Estimating the term…
The invention provides a pharmaceutical composition comprising a synthetic or naturally occurring charged phospholipid, which is formulated into a dosage form for administration to a subject or which is administered as a food additive. Negatively charged phospholipid composition increase the net negative charge on intravascular lipoproteins, enhance the clearance of cholesterol and regulate the function of lipolytic enzymes, retard prothrombin formation and aid in the clearance of virus and bacterial particles. Negatively charged lipid compositions can therefore be administered to humans and animals for the treatment of hyperlipidemia and blood coagulation disorders and to reduce the levels of virus, bacteria, and endotoxins in the blood stream. Positively charged lipid compositions can be administered to delay lipoprotein clearance from the plasma compartment and give longer duration of activity for drugs which are associated with lipoproteins.
A composition comprising a charged phospholipid in the presence of suitable carrier, for administration to a subject.
A method of retarding lipoprotein clearance from a subject, comprising administering to the subject a positively charged phospholipid.
A use of a composition comprising a synthetic or naturally occurring negatively charged phospholipid as a medicament for reducing cholesterol in a subject.
A use of a composition comprising a synthetic or naturally occurring negatively charged phospholipid as a food additive for reducing cholesterol in a subject.
A method of lowering cholesterol in a subject comprising administering to said subject an effective amount of a synthetic or naturally occurring negatively-charged phospholipid.
A method of removing virus particles from the bloodstream of a subject comprising administering to said subject an effective amount of a composition comprising a synthetic or naturally occurring negatively-charged phospholipid.
A method of removing bacteria associated with lipoprotein from the bloodstream of a subject comprising administering to said subject an effective amount of a synthetic or naturally occurring negatively-charged phospholipid.
A method of inhibiting the formation of prothrombin in plasma, comprising admixing with said plasma a synthetic or naturally occurring negatively-charged phospholipid.
The method of any of claims 35 or 4245 wherein said negatively charged phospholipid is phosphatidylinositol.
Dependencies are inferred from the claim text.