US 2003/0158116 A1 · Peptides and compounds that bind to a receptor

Abstract

Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.

Claims18

Dependent claims

A peptide having a molecular weight of less than about 8000 daltons, and comprising a sequence of amino acids (SEQ ID NO:2):

X1 X2 X3 X4 X5 X6 X7
where X1 is C, L, M, P, Q, V;
X2 is F, K, L, N, Q, R, S, T or V;
X3 is C, F, I, L, M, R, S, V or W;
X4 is any of the 20 genetically coded L-amino acids;
X5 is A, D, E, G, K, M, Q, R, S, T, V or Y;
X6 is C, F, G, L, M, S, V, W or Y;
and X7 is C, G, I, K, L, M, N, R or V;
and having a detectable label covalently attached to said peptide.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/083,768Filed 27 Feb 2002

Priority

7 Jun 1996

Published

21 Aug 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

C07K 7/08
Linear peptides containing only normal peptide links: having 12 to 20 amino acids
A61P 7/00
Drugs for disorders of the blood or the extracellular fluid
C07K 7/64
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof: cyclic peptides containing only normal peptide links
C07K 14/521
Cytokines; Lymphokines; Interferons: chemokines

Family

Application08/973,225Continuation · filed 4 Dec 1997

Application08/973,225A 371 of international · filed 4 Dec 1997

Application09/549,090Continuation · filed 13 Apr 2000

Application10/083,768Continuation · filed 27 Feb 2002

US 6,083,913 ARelated patent

US 6,465,430 B1Related patent

US 7,091,311 B2Related patent

US 2003/0158116 A1This patent

From the US filing history. Foreign family members aren’t listed.

Peptides and compounds that bind to a receptor

Life of this patent

Peptides and compounds that bind to a receptor

Life of this patent

Abstract

Claims18