Methods and products for oral care
OwnerDavid Bar-Orinventor
Life of this patent
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Abstract
The invention provides methods, oral care products and kits for treating mouth tissues. In particular, the invention provides methods, oral care products and kits which comprise certain metal-binding peptides, peptide derivatives and peptide dimers that can reduce inflammation of tissues of the mouth and can reduce the damage done by reactive oxygen species (ROS) to such tissues.
Claims214
A method of treating a tissue of an animal's mouth comprising contacting the tissue with an effective amount of a peptide having the formula:
- P1-P2,
- wherein:
- P1 is:
- Xaa1 Xaa2 His:
- or
- Xaa1 Xaa2 His Xaa3;
- P2 is (Xaa4)n;
- Xaa1 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, isoaspartic acid, asparagine, glutamic acid, isoglutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, omithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa2 is glycine, alanine, β-alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa3 is glycine, alanine, valine, lysine, arginine, ornithine, aspartic acid, glutamic acid, asparagine, glutamine or tryptophan;
- Xaa4 is any amino acid;
- and
- n is 0-100;
- or a physiologically-acceptable salt thereof.
A method of treating a disease or condition of a tissue of an animal's mouth comprising contacting the tissue with an effective amount of a peptide having the formula:
- P1-P2,
- wherein:
- P1 is:
- Xaa1 Xaa2 His:
- or
- Xaa1 Xaa2 His Xaa3;
- P2 is (Xaa4)n;
- Xaa1 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, isoaspartic acid, asparagine, glutamic acid, isoglutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa2 is glycine, alanine, β-alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine,- methionine, or α-hydroxymethylserine;
- Xaa3 is glycine, alanine, valine, lysine, arginine, ornithine, aspartic acid, glutamic acid, asparagine, glutamine or tryptophan;
- Xaa4 is any amino acid;
- and
- n is 0-100;
- or a physiologically-acceptable salt thereof.
A method oftreating inflammation of a tissue of an animal's mouth comprising contacting the tissue with an effective amount of a peptide having the formula:
- P1-P2,
- wherein:
- P1 is:
- Xaa1 Xaa2 His:
- or
- Xaa1 Xaa2 His Xaa3;
- P2 is (Xaa4)n;
- Xaa1 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, isoaspartic acid, asparagine, glutamic acid, isoglutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa2 is glycine, alanine, β-alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa3 is glycine, alanine, valine, lysine, arginine, ornithine, aspartic acid, glutamic acid, asparagine, glutamine or tryptophan;
- Xaa4 is any amino acid;
- and
- n is 0-100;
- or a physiologically-acceptable salt thereof.
A method of whitening one or more teeth of an animal comprising contacting a tissue of the animal's mouth with an effective amount of a peptide having the formula:
- P1-P2,
- wherein:
- P1 is:
- Xaa1 Xaa2 His:
- or
- Xaa1 Xaa2 His Xaa3;
- P2 is (Xaa4)n;
- Xaa1 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, isoaspartic acid, asparagine, glutamic acid, isoglutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa2 is glycine, alanine, β-alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa3 is glycine, alanine, valine, lysine, arginine, ornithine, aspartic acid, glutamic acid, asparagine, glutamine or tryptophan;
- Xaa4 is any amino acid;
- and
- n is 0-100;
- or a physiologically-acceptable salt thereof.
A method of reducing the damage done by reactive oxygen species (ROS) to a tissue of an animal's mouth comprising contacting the tissue with an effective amount of a peptide having the formula:
- P1-P2,
- wherein:
- P1 is:
- Xaa1 Xaa2 His:
- or
- Xaa1 Xaa2 His Xaa3;
- P2 is (Xaa4)n;
- Xaa1 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, isoaspartic acid, asparagine, glutamic acid, isoglutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, omithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa2 is glycine, alanine, β-alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa3 is glycine, alanine, valine, lysine, arginine, omithine, aspartic acid, glutamic acid, asparagine, glutamine or tryptophan;
- Xaa4 is any amino acid;
- and
- n is 0-100;
- or a physiologically-acceptable salt thereof.
A method of reducing the concentration of a metal in or on a tissue of an animal's mouth comprising contacting the tissue with an effective amount of apeptide having the formula:
- P1-P2,
- wherein:
- P1 is:
- Xaa1 Xaa2 His:
- or
- Xaa1 Xaa2 His Xaa3;
- P2 is (Xaa4)n;
- Xaa1 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, isoaspartic acid, asparagine, glutamic acid, isoglutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa2 is glycine, alanine, β-alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa3 is glycine, alanine, valine, lysine, arginine, ornithine, aspartic acid, glutamic acid, asparagine, glutamine or tryptophan;
- Xaa4 is any amino acid;
- and
- n is 0-100;
- or a physiologically-acceptable salt thereof.
A method of treating a tissue of an animal's mouth comprising contacting the tissue with an effective amount of a metal-binding peptide having attached thereto a non-peptide, metal-binding functional group.
A method of treating a tissue of an animal's mouth comprising contacting the tissue with an effective amount of a metal-binding peptide dimer of the formula:
- P3-L-P3,
- wherein:
- each P3 may be the same or different and is a peptide which is capable of binding a metal ion;
- and
- L is a chemical group which connects the two P3 peptides through their C-terminal amino acids.
A method of treating a disease or condition of a tissue of an animal's mouth comprising contacting the tissue with an effective amount of a metal-binding peptide dimer of the formula:
- P3-L- P3,
- wherein:
- each P3 may be the same or different and is a peptide which is capable of binding a metal ion;
- and
- L is a chemical group which connects the two P3 peptides through their C-terminal amino acids.
A method oftreating inflammation of a tissue of an animal's mouth comprising contacting the tissue with an effective amount of a metal-binding peptide dimer of the formula:
- P3-L- P3,
- wherein:
- each P3 may be the same or different and is a peptide which is capable of binding a metal ion;
- and
- L is a chemical group which connects the two P3 peptides through their C-terminal amino acids.
A method of whitening one or more teeth of an animal comprising contacting a tissue of the animal's mouth with an effective amount of a metal-binding peptide dimer of the formula:
- P3-L-P3,
- wherein:
- each P3 may be the same or different and is a peptide which is capable of binding a metal ion;
- and
- L is a chemical group which connects the two P3 peptides through their C-terminal amino acids.
A method of reducing the damage done by reactive oxygen species (ROS) to a tissue of an animal's mouth comprising contacting the tissue with an effective amount of a metal-binding peptide dimer of the formula:
- P3-L-P3,
- wherein:
- each P3 may be the same or different and is a peptide which is capable of binding a metal ion;
- and
- L is a chemical group which connects the two P3 peptides through their C-terminal amino acids.
A method of reducing the concentration of a metal in or on a tissue of an animal's mouth comprising contacting the tissue with an effective amount of a metal-binding peptide dimer of the formula:
- P3-L-P3,
- wherein:
- each P3 may be the same or different and is a peptide which is capable of binding a metal ion;
- and
- L is a chemical group which connects the two P3 peptides through their C-terminal amino acids.
An oral care product comprising a peptide having the formula:
- P1-P2,
- wherein:
- P1 is:
- Xaa1 Xaa2 His:
- or
- Xaa1 Xaa2 His Xaa3;
- P2 is (Xaa4)n;
- Xaa1 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, isoaspartic acid, asparagine, glutamic acid, isoglutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, omithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa2 is glycine, alanine, β-alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa3 is glycine, alanine, valine, lysine, arginine, ornithine, aspartic acid, glutamic acid, asparagine, glutamine or tryptophan;
- Xaa4 is any amino acid;
- and
- n is 0-100;
- or a physiologically-acceptable salt thereof.
An oral care device comprising a peptide having the formula:
- P1-P2,
- wherein:
- P1 is:
- Xaa1 Xaa2 His:
- or
- Xaa1 Xaa2 His Xaa3;
- P2 is (Xaa4)n;
- Xaa1 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, isoaspartic acid, asparagine, glutamic acid, isoglutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa2 is glycine, alanine, β-alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa3 is glycine, alanine, valine, lysine, arginine, omithine, aspartic acid, glutamic acid, asparagine, glutamine or tryptophan;
- Xaa4 is any amino acid;
- and
- n is 0-100;
- or a physiologically-acceptable salt thereof.
An oral care composition comprising a pharmaceutically-acceptable carrier and a peptide having the formula:
- P1-P2,
- wherein:
- P1 is:
- Xaa1 Xaa2 His:
- or
- Xaa1 Xaa2 His Xaa3;
- P2 is (Xaa4)n;
- Xaa1 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, isoaspartic acid, asparagine, glutamic acid, isoglutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, omithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa2 is glycine, alanine, β-alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa3 is glycine, alanine, valine, lysine, arginine, ornithine, aspartic acid, glutamic acid, asparagine, glutamine or tryptophan;
- Xaa4 is any amino acid;
- and
- n is 0-100;
- or a physiologically-acceptable salt thereof.
An oral care product comprising a metal-binding peptide having attached thereto a non-peptide, metal-binding functional group.
An oral care product comprising a metal-binding peptide dimer of the formula:
- P3-L- P3,
- wherein:
- each P3 may be the same or different and is a peptide which is capable of binding a metal ion;
- and
- L is a chemical group which connects the two P3 peptides through their C-terminal amino acids.
An oral care device comprising a metal-binding peptide dimer of the formula:
- P3-L- P3,
- wherein:
- each P3 may be the same or different and is a peptide which is capable of binding a metal ion;
- and
- L is a chemical group which connects the two P3 peptides through their C-terminal amino acids.
An oral care composition comprising a pharmaceutically-acceptable carrier and a metal-binding peptide dimer of the formula:
- P3-L- P3,
- wherein:
- each P3 may be the same or different and is a peptide which is capable of binding a metal ion;
- and
- L is a chemical group which connects the two P3 peptides through their C-terminal amino acids.
A kit comprising an oral care product, the oral care product comprising a peptide having the formula:
- P1-P2,
- wherein:
- P1 is:
- Xaa1 Xaa2 His:
- or
- Xaa1 Xaa2 His Xaa3;
- P2 is (Xaa4)n;
- Xaa1 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, isoaspartic acid, asparagine, glutamic acid, isoglutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, omithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa2 is glycine, alanine, β-alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa3 is glycine, alanine, valine, lysine, arginine, omithine, aspartic acid, glutamic acid, asparagine, glutamine or tryptophan;
- Xaa4 is any amino acid;
- and
- n is 0-100;
- or a physiologically-acceptable salt thereof.
A kit comprising an oral care device, the oral care device comprising a peptide having the formula:
- P1-P2,
- wherein:
- P1 is:
- Xaa1 Xaa2 His:
- or
- Xaa1 Xaa2 His Xaa3;
- P2 is (Xaa4)n;
- Xaa1 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, isoaspartic acid, asparagine, glutamic acid, isoglutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa2 is glycine, alanine, β-alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa3 is glycine, alanine, valine, lysine, arginine, omithine, aspartic acid, glutamic acid, asparagine, glutamine or tryptophan;
- Xaa4 is any amino acid;
- and
- n is 0-100;
- or a physiologically-acceptable salt thereof
A kit comprising an oral care composition, the composition comprising a pharmaceutically-acceptable carrier and a peptide having the formula:
- P1-P2,
- wherein:
- P1 is:
- Xaa1 Xaa2 His:
- or
- Xaa1 Xaa2 His Xaa3;
- P2 is (Xaa4)n;
- Xaa1 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, isoaspartic acid, asparagine, glutamic acid, isoglutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, omithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa2 is glycine, alanine, β-alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, ornithine, phenylalanine, tyrosine, tryptophan, cysteine, methionine, or α-hydroxymethylserine;
- Xaa3 is glycine, alanine, valine, lysine, arginine, omithine, aspartic acid, glutamic acid, asparagine, glutamine or tryptophan;
- Xaa4 is any amino acid;
- and
- n is 0-100;
- or a physiologically-acceptable salt thereof.
A kit comprising an oral care product, the product comprising a metal-binding peptide having attached thereto a non-peptide, metal-binding functional group.
A kit comprising an oral care product, the product comprising a metal-binding peptide dimer of the formula:
- P3-L- P3,
- wherein:
- each P3 may be the same or different and is a peptide which is capable of binding a metal ion;
- and
- L is a chemical group which connects the two P3 peptides through their C-terminal amino acids.
A kit comprising an oral care device, the device comprising a metal-binding peptide dimer of the formula:
- P3-L-P3,
- wherein:
- each P3 may be the same or different and is a peptide which is capable of binding a metal ion;
- and
- L is a chemical group which connects the two P3 peptides through their C-terminal amino acids.
A kit comprising an oral care composition, the composition comprising a pharmaceutically-acceptable carrier and a metal-binding peptide dimer of the formula:
- P3-L-P3,
- wherein:
- each P3 may be the same or different and is a peptide which is capable of binding a metal ion;
- and
- L is a chemical group which connects the two P3 peptides through their C-terminal amino acids.
Dependencies are inferred from the claim text.