Metastatic breast and colon cancer regulated genes
OwnerKlaus Gieseinventor
Life of this patent
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Abstract
Gene sequences as shown in SEQ ID NOS: 1-85 have been found to be significantly associated with metastatic potential of cancer cells, especially breast and colon cancer cells. Methods are provided for determining the risk of metastasis of a tumor, which involve determining whether a tissue sample from a tumor expresses a polypeptide encoded by a gene as shown in SEQ ID NOS: 1-85, or a substantial portion thereof.
Claims20
An isolated and purified human protein comprising an amino acid sequence which is at least 85% identical to an amino acid sequence encoded by a nucleotide sequence selected from the group consisting of SEQ ID NOS:
- 1-63 or the complement thereof.
A fusion protein which comprises a first protein segment and a second protein segment fused to each other by means of a peptide bond, wherein the first protein segment consists of at least six contiguous amino acids selected from an amino acid sequence encoded by a nucleotide sequence selected from the group consisting of SEQ ID NOS:
- 1-63 or the complement thereof.
A preparation of antibodies which specifically bind to a human protein which comprises an amino acid sequence encoded by a nucleotide sequence selected from the group consisting of SEQ ID NOS:
- 1-63 or the complement thereof.
A method for detecting metastatic tumor cells in a tissue sample, comprising the step of:
- measuring in said tissue sample an expression product of a gene which comprises a coding sequence selected from the group consisting of SEQ ID NOS:
- 1, 2, 4, 5, 9, 11, 13, 14, 18, 19, 20, 22, 24, 26, 29, 30, 33, 35, 36, 38-41, 45, 48, 52, 55, 57, 58, 60, 63-66, 69-74, 76, 80, 82, and 83, wherein a tissue sample which expresses the product is categorized as containing metastatic tumor cells.
A method for detecting metastatic tumor cells in a tissue sample, comprising the step of:
- measuring in a tissue sample an expression product of a gene which comprises a sequence selected from the group consisting of SEQ ID NOS:
- 3, 7, 8, 10, 12, 15-17, 21, 23, 25, 28, 31, 34, 37, 42-44, 46, 47, 49-51, 53, 59, 61, 62, 67, 68, 75, 77-79, 81, 84, and 85, wherein a tissue sample which does not express the product is categorized as metastatic.
A method for determining metastatic potential in a tissue sample, comprising the step of:
- measuring in a tissue sample an expression product of a gene which comprises a sequence selected from the group consisting of SEQ ID NOS:
- 1, 2, 4, 5, 9, 11, 13, 14, 18, 19, 20, 22, 24, 26, 29, 30, 33, 35, 36, 38-41, 45, 48, 52, 55, 57, 58, 60, 63-66, 69-74, 76, 80, 82, and 83, wherein a tissue sample which expresses the product is categorized as having metastatic potential.
A method for determining metastatic potential in a tissue sample, comprising the step of:
- measuring in a tissue sample an expression product of a gene which comprises a sequence selected from the group consisting of SEQ ID NOS:
- 3, 7, 8, 10, 12, 15-17, 21, 23, 28, 31, 34, 37, 42-44, 46, 47, 49-51, 53, 59, 61, 62, 67, 68, 75, 77-79, 81, 84, and 85, wherein a tissue sample which does not express the product is categorized as having metastatic potential.
A method of predicting the propensity for metastatic spread of a breast tumor preferentially to bone or lung, comprising the steps of:
- measuring in a breast tumor sample an expression product of a gene which comprises a sequence selected from the group consisting of SEQ ID NO:
- 1, 5, 11, 18, 20, 22, 24, 30, 33, 35, 36, 38, 45, 52, 58, 65, 66, 70, 74, 76, and 80,
- wherein a breast tumor sample which expresses the product is categorized as having a propensity to metastasize to bone or lung.
A method of predicting propensity for metastatic spread of a breast tumor preferentially to lung, comprising the steps of:
- measuring in a breast tumor sample an expression product of a gene which comprises a sequence selected from the group consisting of SEQ ID NOS:
- 2, 4, 9, 13, 14, 19, 26, 29, 39-41, 48, 55, 57, 60, 63, 64, 72, 73, 82, and 83,
- wherein a breast tumor sample which expresses the product is characterized as having a propensity to metastasize to lung.
A method of predicting propensity for metastatic spread of a colon tumor, comprising the steps of:
- measuring in a colon tumor sample an expression product of a gene which comprises the nucleotide sequence shown in SEQ ID NO:
- 56,
- wherein a colon tumor sample which expresses the product is characterized as having a low propensity to metastasize.
Dependencies are inferred from the claim text.