Colon specific gene and protein
AssigneeHuman Genome Sciences, Inc.
InventorsDaniel R. Soppet, Yi Li, Patrick J. Dillon
Life of this patent
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Abstract
Human colon specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for colon cancer and as an agent to determine if colon cancer has metastasized. Also disclosed are antibodies specific to the colon specific gene polypeptides which may be used to target cancer cells and be used as part of a colon cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are also disclosed.
Claims20
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide encoding the polypeptide comprising amino acid 1 to amino acid 158 as set forth in SEQ ID NO:
- 2;
- (b) a polynucleotide which encodes a mature polypeptide encoded by the DNA contained in ATCC Deposit No. 97129;
- (c) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a) or (b);
- and
- (d) a polynucleotide fragment of the polynucleotide of (a), (b) or (c).
An isolated polynucleotide having at least 10 base pairs which hybridizes to and which has at least 70% identity to a member selected from the group consisting of:
- (a) RNA-transcribed from a human gene, said gene including DNA having at least a 90% identity to the DNA selected from the group consisting of SEQ ID NO:
- 1;
- and
- (b) DNA corresponding to the RNA of (a).
A process for diagnosing a disorder of the colon in a host comprising:
- determining transcription of a human gene in a sample derived from non-colon tissue of a host, said gene having a coding portion which includes DNA having at least 90% identity to DNA selected from the group consisting of the DNA of SEQ ID NO:
- 1, whereby said transcription indicates a disorder of the colon in-the host.
Dependencies are inferred from the claim text.