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OwnerDavid James Craik, Norello Lee Daly +1inventors
InventorsDavid James Craik, Norello Lee Daly, Clements Waim-Kunduane Waine
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The present invention relates generally to a molecular framework having a cyclic structure. More particularly, the present invention provides cyclic proteins and derivatives thereof in which particular turns and other elements of the molecular structure are held in defined orientations with respect to each other. The cyclic proteins of the present invention provide a molecular framework for the introduction of particular amino acids or heterologous amino acid sequences to facilitate the presentation of biological activities associated with these heterologous amino acid sequences. The molecular framework of the present invention may be naturally cyclic or may be a cyclized derivative of a linear molecular or may be a linear derivative of a cyclized molecule. The present invention contemplates the use of the molecular framework with or without particular amino acids inserted or substituted thereon for the treatment of or prophylaxis of disease conditions in animals, mammals (including humans) and plants.
An isolated molecule which acts as a molecular framework for exogenous amino acids or amino acid sequences, said molecule comprising a sequence of amino acids or analogues thereof forming a cyclic backbone wherein the cyclic backbone comprises sufficient disulfide bonds or chemical equivalents thereof to confer knotted topology on the three-dimensional structure and having the following structure:—
An isolated molecule which acts as a molecular framework for exogenous amino acids or amino acid sequences, said molecule comprising a sequence of amino acids or analogues thereof forming a cyclic backbone and wherein said cyclic backbone comprises sufficient disulfide bonds or chemical equivalents thereof, to confer a knotted topology on the three-dimensional structure of said cyclic backbone and wherein at least one exposed amino acid residue on a beta turn and/or other part of the backbone is inserted or substituted or otherwise grafted relative to the naturally occurring amino acid sequence.
A method of generating a molecule exhibiting a biological property or activity not normally associated with the naturally occurring molecule, said method comprising grafting onto said molecule one or more exogenous amino acid residues wherein said molecule comprises a sequence of amino acids or analogues thereof forming a cyclic backbone wherein the cyclic backbone comprises sufficient disulfide bonds or chemical equivalents thereof to confer knotted topology on the three-dimensional structure and having the following structure:—
Dependencies are inferred from the claim text.