Increasing function of organs having reduced red blood cell flow
AssigneeBiopure Corporation
InventorsEdward E. Jacobs JR., Carl W. Rausch
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method of therapeutically, or prophylactically, treating a vertebrate to increase tissue oxygenation, or maintain issue oxygenation, in tissue of a vertebrate wherein the tissue has a reduced red blood cell flow, and wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance. The method comprises introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
Claims24
A method for increasing tissue oxygenation and, consequently, increasing organ function of a vertebrate, while the organ has reduced oxygen delivery due to at least one partial obstruction of a blood vessel within the circulatory system of the vertebrate, and wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of polymerized hemoglobin, thereby increasing function of the organ.
A method for increasing tissue oxygenation and, consequently, increasing organ function of a vertebrate, wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance, while the organ has reduced oxygen delivery due to at least one partial obstruction of a blood vessel within the circulatory system of the vertebrate, comprising, introducing into the circulatory system of the vertebrate at least one dose of a polymerized hemoglobin solution wherein said hemoglobin solution has:
- a) a hemoglobin concentration between about 120 grams/liter and about 140 grams/liter;
- b) a methemoglobin content less than 15 percent by weight;
- c) an oxyhemoglobin content less than or equal to 10 percent by weight;
- d) an endotoxin concentration less than 0.5 endotoxin units per milliliter;
- e) less than, or equal to, 15 percent by weight polymerized hemoglobin with a molecular weight greater than 500,000 Daltons;
- and
- f) less than, or equal to, 10 percent by weight polymerized hemoglobin with a molecular weight less than or equal to 65,000 Daltons, thereby increasing function of the organ.
A method for increasing tissue oxygenation and, consequently, increasing organ function of a vertebrate, while the organ has reduced oxygen delivery due to at least one partial obstruction of a blood vessel within the circulatory system of the vertebrate, and wherein the vertebrate has a major vessel hematocrit of at least about 30% and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of polymerized hemoglobin, thereby increasing function of the organ.
A method for increasing tissue oxygenation and, consequently, increasing organ function of a vertebrate, while the organ has reduced oxygen delivery due to a decrease in a population of blood vessels associated with the organ, and wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of polymerized hemoglobin, thereby increasing function of the organ.
A method for increasing tissue oxygenation and, consequently, increasing organ function of a vertebrate, while the organ has reduced oxygen delivery due to a cardiogenic dysfunction of the heart of the vertebrate, and wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of polymerized hemoglobin, thereby increasing function of the organ.
A method for increasing tissue oxygenation and, consequently, increasing organ function of a vertebrate, while the organ has reduced oxygen delivery due to a decrease in a population of blood vessels associated with the organ, and wherein the vertebrate has a major vessel hematocrit of at least about 30% and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of polymerized hemoglobin, thereby increasing function of the organ.
A method for increasing tissue oxygenation and, consequently, increasing organ function of a vertebrate, while the organ has reduced oxygen delivery due to a cardiogenic dysfunction of the heart of the vertebrate, and wherein the vertebrate has a major vessel hematocrit of at least about 30% and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of polymerized hemoglobin, thereby increasing function of the organ.
A method for increasing tissue oxygenation and, consequently, increasing organ function of a vertebrate, wherein the vertebrate has a major vessel hematocrit of at least about 30% and at least a normal systemic vascular resistance, while the organ has reduced oxygen delivery due to at least one partial obstruction of a blood vessel within the circulatory system of the vertebrate, comprising introducing, into the circulatory system of the vertebrate, at least one dose of a polymerized hemoglobin solution wherein said hemoglobin solution has:
- a) a hemoglobin concentration between about 120 grams/liter and about 140 grams/liter;
- b) a methemoglobin content less than 15 percent by weight;
- c) an oxyhemoglobin content less than or equal to 10 percent by weight;
- d) an endotoxin concentration less than 0.5 endotoxin units per milliliter;
- e) less than, or equal to, 15 percent by weight polymerized hemoglobin with a molecular weight greater than 500,000 Daltons;
- and
- f) less than, or equal to, 10 percent by weight polymerized hemoglobin with a molecular weight less than or equal to 65,000 Daltons, thereby increasing function of the organ.
Dependencies are inferred from the claim text.