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US 2003/0158089 A1Published application
Administrative agents via the SMVT transporter
AssigneeXenoPort, Inc.
InventorsMark A. Gallop, Kenneth C. Cundy, Noa Zerangue, Feng Xu
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AssigneeXenoPort, Inc.
InventorsMark A. Gallop, Kenneth C. Cundy, Noa Zerangue, Feng Xu
Estimating the term…
Disclosed herein are conjugates comprising a therapeutic agent (e.g., a drug) which is linked to a conjugate moiety that is itself, or itself in combination with the agent, is a good substrate for the sodium dependent multi-vitamin transporter (SMVT). The conjugates have a molecular weight below 1500 daltons and exhibit increased uptake via SMVT through the cells lining the gastrointestinal lumen, and hence higher bioavailability, when administered orally compared to the therapeutic agent itself Also disclosed are methods of delivering agents that, as a result of linkage to a conjugate moiety, are good substrates of the SMVT transporter. Further disclosed are methods of screening conjugates or conjugate moieties, linked or linkable to a therapeutic agent, for capacity to be transported as substrates through the SMVT transporter.
A method of delivering an agent to a patient, comprising:
A conjugate comprising an agent cleavably linked to a conjugate moiety, the conjugate being a substrate for an SMVT transporter, the conjugate having a molecular weight of less than 1,500 Da and a Vmax of at least 5% of biotin for the SMVT transporter, wherein the agent without the conjugate moiety, or a metabolite of the agent, has a pharmacological activity, and the conjugate has a greater Vmax for the SMVT transporter than the agent without the conjugate moiety.
A method of screening a conjugate for transport by an SMVT transporter, comprising:
A method of making a pharmaceutical composition, comprising
A method of making a pharmaceutical product, comprising:
Dependencies are inferred from the claim text.