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US 2003/0158085 A1Published application
Aquaporin-8 variant
AssigneeIncyte Corporation
InventorsMichael G. Walker, Wayne Volkmuth, Tod M. Klingler
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Abstract
The invention provides a mammalian cDNA which encodes a mammalian AQP8V. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of pancreatic disorders, particularly type I diabetes. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
Claims36
An isolated polypeptide selected from the group consisting of:
- a) a polypeptide comprising an amino acid sequence of residues M49 to R303 of SEQ ID NO:
- 1,
- b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence of a), and
- c) an immunogenic fragment of a polypeptide having an amino acid sequence of a).
1 more element
Dependencies are inferred from the claim text.