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AssigneeThe Trustees of the University of Pennsylvania
InventorsCharles P. Emerson, Gurtej Kaur Dhoot
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Nucleic acid sequences encoding members of a new subfamily of sulfatases and polypeptides encoded thereby are provided. Compositions and methods of modulating sulfatases of this new subfamily to modify growth properties and differentiation of cells, as well as the ability of cells to prevent viral entry and to prevent recruitment of lymphocytes to a site of inflammation are also provided. The compositions and methods are useful in treating cancer and inhibiting metastases, promoting differentiation of stem cells into muscle, neural and renal cells and inhibiting viral infection and inflammation. In addition, functional embryonic techniques for identification and characterization of developmental regulatory genes such as these sulfatases are provided.
A nucleic acid sequence encoding a Sulf-1 or Sulf-2 protein.
A polypeptide comprising an amino acid sequence of Sulf-1 or Sulf-2.
A method of modifying growth properties of cells comprising modulating levels or activity of Sulf-1 or Sulf-2 in the cells.
A method of promoting differentiation of stem cells into muscle, neural or renal cells comprising modulating levels of Sulf-1 or Sulf-2 in the stem cells.
A method of treating musculoskeletal, neural or renal degenerative disorders comprising promoting the differentiation of stem cells into muscle cells, neural cells or renal cells by modulating Sulf-1 or Sulf-2 levels in the stem cells and transplanting the differentiated cells into areas of degeneration.
A method of treating musculoskeletal, neural or renal degenerative disorders comprising modulating Sulf-1 or Sulf-2 levels or activity to initiate growth of healthy cells and to heal diseased cells in these disorders.
A composition for modulating growth properties or differentiation of cells comprising an agent which modulates Sulf-1 or Sulf-2 levels or activity in a cell.
A method for inhibiting infection of cells by viruses which utilize sulfated heparin proteoglycans for entry into the cells comprising increasing levels or activity of Sulf-1 or Sulf-2 in the cells.
A composition for inhibiting infection of cells by viruses which utilize sulfated heparin proteoglycans for entry into the cells comprising an agent which increases Sulf-1 or Sulf-2 levels or activity in the cell.
A method for modulating recruitment of lymphocytes by cells to sites of inflammation comprising modulating levels or activity of Sulf-1 or Sulf-2 in the cells.
A composition for modulating recruitment of lymphocytes by cells to sites of inflammation comprising an agent which modulates Sulf-1 or Sulf-2 levels or activity in the cells.
A functional embryonic technique for identification of developmental regulatory genes comprising:
Dependencies are inferred from the claim text.