Method for testing the degradation of polymeric materials
AssigneeThe Research Foundation of State University of New York
InventorsJoseph A. Gardella JR., Jiaxing Chen, Norma L. Hernandez de Gatica, Joo-Woon Lee
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Abstract
The present invention provides a novel method for monitoring the surface concentration of a drug in a polymer blend matrix and the reaction kinetics of the biodegradable polymers. Detailed information on surface concentration, degradation rates, degradation kinetics and mechanism, is provided by using Time-of-Flight Secondary Ion Mass Spectrometry (ToF SIMS) measurements. Also provided is a method for determining oligomers in hydrolyzed biodegradable polymers.
Claims26
A method for simultaneous determination of surface drug concentration and reaction kinetics of a polymer blend matrix comprising the steps of:
- providing a polymer blend matrix;
- initiating degradation of the polymer blend matrix;
- subjecting the degraded polymer blend matrix to high mass and low mass ToF SIMS spectral analysis;
- identifying and quantifying oligomers from the high mass ToF SIMS;
- identifying and quantifying surface drug concentration from the ToF SIMS spectra;
- and,
- calculating the rate of formation of one or more oligomers and the rate of change of surface concentration of drug.
A method for determination of oligomers in a hydrolyzed biodegradable polymer comprising the steps of:
- providing a biodegradable polymer;
- initiating hydrolytic degradation of the
- biodegradable polymer;
- subjecting the degraded biodegradable polymer to high mass ToF SIMS spectral analysis;
- and
- identifying and quantifying oligomers from the high mass ToF SIMS.
Dependencies are inferred from the claim text.