Expression of heterologous genes from an IRES translational cassette in retroviral vectors
AssigneeAarhus University
InventorsFinn Skou Pedersen, Thomas Jesperson, Mogens Duch
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Abstract
The present invention relates to a retroviral vector which expresses a gene, e.g. for therapeutic use and/or of viral origin, under the translational control of an internal ribosomal entry site (IRES) resulting in the efficient translation of said gene.
Claims39
A retroviral vector comprising a complete retroviral genome wherein at least all genes essential for replication of the retrovirus remain functional, said vector additionally comprising a heterologous nucleic acid sequence preceded by a heterologous internal ribosome entry site IRES resulting in the translation of said sequence under the control of the IRES.
A replication-defective retroviral vector comprising a gene encoding a protein which is capable to initiate infection, wherein said gene is under translational control of a heterologous internal ribosome entry site IRES.
Dependencies are inferred from the claim text.