Engineered recombinant molecule that regulates humoral and cellular effector functions of the immune system
OwnerWilliam L. Fodor, Maryellen Pizzolatoinventors
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Abstract
Recombinant chimeric molecules that include at least a domain capable of regulating the humoral effector functions of the immune system and another domain capable of regulating the cellular effector functions of the immune system are provided. Recombinant DNA constructs having DNA sequences encoding the above mentioned chimeric proteins are provided. Cloning vectors incorporating the above DNA constructs and cells transformed with the vectors and host cells containing such vectors are also provided. Transgenic cells, tissues, organs, and animals incorporating the above-mentioned chimeric molecules are provided.
Claims22
A chimeric protein capable of inhibiting both cellular and humoral immune responses.
A chimeric protein comprising a domain having C5b-9 inhibitory activity and a domain having T Cell inhibitory activity.
A chimeric DNA construct comprising a domain derived from a DNA sequence encoding a domain having C5b-9 inhibitory activity and a DNA sequence encoding a domain having T Cell inhibitory activity.
A chimeric protein comprising a domain having C3 inhibitory activity and a domain having T Cell inhibitory activity.
Dependencies are inferred from the claim text.