Isolated GAGE-7B and 8 proteins
AssigneeLudwig Institute for Cancer Research
InventorsOlivier De Backer, Benoit Van den Eynde, Thierry Boon-Falleur
Life of this patent
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Abstract
The invention relates to new members of the GAGE family referred to as GAGE-7B and GAGE-8. There are differences between these two molecules and the previously described members of the GAGE family on the genomic DNA, complementary DNA, and amino acid level.
Claims36
An isolated nucleic acid molecule which encodes a protein which is encoded by a nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:
- 1, 2or3.
Isolated peptide which comprises at least the first 74 amino acids of the protein encoded by SEQ ID NO:
- 1, 2 or 3, and no more than the complete protein encoded by SEQ ID NO:
- 1, 2or3.
A method for determining expression of a GAGE gene in a sample, comprising contacting said sample with at least one oligonulceotide primer selected from the group consisting of SEQ ID NOS:
- 4, 5 and 6, and determining hybridization of said oligonucleotide primer to a target mRNA molecule as a determination of GAGE expression in said sample.
An isolated nucleic acid molecule comprising at least nucleotides 107-350 of the nucleotide sequence set forth in SEQ ID NO:
- 1.
An isolated nucleic acid molecule comprising at least nucleotides 92-335 of the nucleotide sequence set forth in SEQ ID NO:
- 2.
An isolated nucleic acid molecule consisting of nucleotides 453-650 of the nucleotide sequence set forth in SEQ ID NO:
- 8.
A method for determining expression of a GAGE gene in a sample, comprising contacting said sample with at least one oligonucleotide primer selected from the group consisting of nucleotides 453-470 of SEQ ID NO:
- 8, and nucleotides 633-650 of SEQ ID NO:
- 8, and determining hybridization to a target mRNA molecule as an indication of expression of a GAGE gene in said sample.
An isolated nucleic acid molecule consisting of a nucleotide sequence which encodes an MHC binding peptide of a GAGE gene.
An isolated nucleic acid molecule comprising nucleotides 7109-7659 of SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.