Diagnostic assay for transmissible spongiform encephalopathies
AssigneeUniversite De Geneve
InventorsDenis Francois Hochstrasser, Jean-Charles Sanchez, Catherine Gabrielle Zimmermann, Elisabeth Guillaume
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Abstract
Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for TSEs, especially CJD. The invention provides a diagnostic assay for either of these markers, preferably by enzyme immunoassay using anti-H-FABP or B-FABP antibody. Since H-FABP is also a marker for acute myocardial infarction (AMI), to distinguish CJD from AMI requires an assay specific to AMI, e.g. using troponin-I or creatine kinase-MB as a marker, also to be carried out.
Claims8
A method of diagnostic assay for a transmissible spongiform encephalopathy (TSE) or the possibility thereof in a sample of body fluid taken from a subject suspected of suffering from the TSE, which comprises determining the concentration of heart or brain fatty acid binding protein (H-FABP or B-FABP) in the sample.
A method according to any preceding claim, wherein the H-FABP or B-FABP assay is carried out on a blood plasma or serum sample.
Dependencies are inferred from the claim text.