Use of Axl receptor for diagnosis and treatment of renal disease
OwnerOrna Morinventor
Life of this patent
Estimating the term…
Abstract
The invention is directed to a process of identifying a compound capable of inhibiting the activity of a human Ax1 receptor that comprises contacting the Ax1 receptor or cells expressing the Ax1 receptor with the compound; measuring the Ax1 receptor activity in the presence of the compound ; and comparing the activity measured to that measured in the absence of the compound under controlled conditions, wherein a decrease identifies the compound as being capable of inhibiting the activity. Therapeutic and diagnostic applications are also described.
Claims35
A process of identifying a compound capable of inhibiting the activity of a human Ax1 receptor that comprises the steps of:
- (iv) contacting the Ax1 receptor or cells expressing the Ax1 receptor with the compound;
- (v) measuring the Ax1 receptor activity in the presence of the compound and
- (vi) comparing the activity measured in step (ii) to that measured in the absence of the compound under controlled conditions, wherein a decrease identifies the compound as being capable of inhibiting the activity.
A method of diagnosing nephropathy in a subject comprising determining in a sample from the subject the level of an Ax1 receptor polypeptide, wherein a higher level of the polypeptide compared to the level in a subject free of nephropathy is indicative of nephropathy.
A process of identifying a compound capable of inhibiting the activity of a human Ax1 receptor by screening a plurality of compounds that comprises the steps of:
- (i) contacting the Ax1 receptor or cells expressing the Ax1 receptor with the plurality of compounds;
- (ii) measuring the Ax1 receptor activity in the presence of the plurality of compounds;
- (iii) comparing the activity measured in step (ii) to that measured in the absence of the plurality of compounds under controlled conditions, wherein a decrease identifies the plurality of compounds as being capable of inhibiting the activity;
- and
- (v) separately determining which compound or compounds present in the plurality inhibit the activity of a human Ax1 receptor.
Dependencies are inferred from the claim text.