US 2003/0157558 A1 · Novel guanosine triphosphate-binding protein-coupled receptors, genes thereof and production and use of the same

Abstract

Nine novel genes sustaining hydrophobic domains, which are estimated to be seven transmembrane domains characteristic to G protein-coupled receptors, are successfully isolated by human tissue cDNA screening. These genes and proteins which are the expression products thereof are usable in screening ligands, screening agonists or antagonists which are useful as drugs, diagnosing diseases in which these gene participate, etc.

Claims17

Dependent claims

A DNA that encodes a guanosine triphosphate-binding protein-coupled receptor, wherein said DNA is selected from the group consisting of the following (a) to (d):

(a) a DNA encoding a protein comprising the amino acid sequence of any one of SEQ ID NOs:
1 to 4 and 17 to 21;
(b) a DNA comprising a coding region of the nucleotide sequence of any one of SEQ ID NOs:
5 to 8 and 22 to 26;
(c) a DNA encoding a protein comprising the amino acid sequence of any one of SEQ ID NOs:
1 to 4 and 17 to 21 in which one or more amino acids are substituted, deleted, added, and/or inserted;
and
(d) a DNA hybridizing under stringent conditions to the DNA comprising the nucleotide sequence of any one of SEQ ID NOs:
5 to 8 and 22 to 26.

6 more elements

Dependencies are inferred from the claim text.

Novel guanosine triphosphate-binding protein-coupled receptors, genes thereof and production and use of the same

Life of this patent

Novel guanosine triphosphate-binding protein-coupled receptors, genes thereof and production and use of the same

Life of this patent

Abstract

Claims17