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US 2003/0157555 A1Published application
Diagnosis and treatment for immunoglobulin E ( IgE) implicated disorders
OwnerBinie V. Lipps, Frederick W. Lippsinventors
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OwnerBinie V. Lipps, Frederick W. Lippsinventors
Estimating the term…
Human saliva is used as a non-invasive source instead of invasive blood serum plasma for detection and assay of endogenously present proteins; nerve growth factor (NGF), myoglobin, Insulin, adenosine deaminase (ADA), including immunoglobulin E (IgE). It was discovered that people having high levels of IgE, show high levels in comparison to the normal controls of NGF, myoglobin, insulin and ADA, disrupting the homeostasis for these proteins. Oral administration of a synthetic peptide LT-10 disclosed in U.S. Pat. No. 5,576,297 having sequence L K A M D P T P P L reduces IgE level in humans and bring other proteins into homeostasis, for example, NGF, myoglobin, insulin and ADA and possibly other proteins and cytokines. Composition of synthetic LT-10 is advocated as a treatment for IgE implicated disorders such as asthma, depression and various types of autoimmune diseases, such as erythematosus (SLE); Rheumatoid arthritis Sjogren's syndrome; Reiter's syndrome; Diabetes mellitus (insulin-dependent); Graves' disease; Addison's disease; Hodgkin's disease, etc.
The invention relates to the discovery of the presence of endogenous proteins;
This invention relates to the introduction of use of saliva as a non-invasive source for detection and assay of endogenously present proteins;
The invention discovered that people having high levels of IgE show higher levels in comparison to controls, of NGF, myoglobin, insulin and in asthma patients high level of ADA, disrupting the homeostasis for these proteins.
Composition of synthetic LT-10 is advocated as a treatment for IgE implicated disorders. Synthetic LT-10 consists often amino acids:
Composition of synthetic LT-10 as a treatment for having high level of IgE, causes decrease in level of IgE. Decrease in IgE level brings the homeostasis of other proteins to normal state which improves the symptoms in the afflicted people for asthma, depression, diabetes and various types of autoimmune diseases, such as erythematosus (SLE);
People having elevated level of IgE also show high level of NGF may be prone to the symptoms of neuropathy. Likewise high level of myoglobin may cause heart problems. Elevated level of insulin shows pancreases is affected. LT-10 treatment decreases the level of IgE which brings the homeostasis for NGF, myoglobin, insulin, ADA and may be other proteins and cytokines to normal status.
A method for assaying a human endogenous protein of interest, said method comprising
A method for reducing serum proteins selected from the group consisting of IgE, NGF, Insulin, Myoglobin and ADA in a human, comprising
Dependencies are inferred from the claim text.