Method for diagnosing schizophrenia using objective indices
OwnerHiroyuki Nawa, Hitoshi Takahashi +1inventors
InventorsHiroyuki Nawa, Hitoshi Takahashi, Shuji Iritani
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Abstract
Provided is a method for diagnosing whether or not a subject suffers from schizophrenia, comprising the steps of taking a sample containing nucleic acid and/or protein from the subject, quantifying nucleic acid and/or protein corresponding to at least one gene selected from the group consisting of genes listed in Table 1 below, fragments thereof, and complementary nucleic acid thereof, and diagnosing whether or not the subject suffers from schizophrenia by using a quantitative value of at least one protein, a fragment thereof or the nucleic acid.
Claims3
A method of diagnosing whether or not said subject suffers from schizophrenia, comprising the steps of:
- taking a sample containing, for example, nucleic acid and/or protein from the subject;
- quantifying nucleic acid and/or protein corresponding to at least one gene selected from the group consisting of genes listed below, fragments thereof, and complementary nucleic acid thereof:
- CCAAT-binding transcription factor subunit B (M59079);
- Transcription regulating interferon stimulating gene factor 3 γ subunit (M87503);
- DNA topoisomerase 1 (JO3250);
- Migration inhibitory factor associated protein 8 (X06234);
- Growth arrest & DNA-damage inducible protein (M60974);
- MacMARCKS(X70326);
- ERBB-3 receptor protein-tyrosine kinase precursor (M29366, M34309);
- Precancer gene c-jun (JO4111);
- Phospholipase A2 (M86400);
- Erythrocyte urea transporter (U35735);
- T-lymphocyte maturation-associated protein MAL(M15800);
- Calcium/calmodulin-dependent protein kinase type IV catalytic subunit(L24959);
- Interleukin-10 precursor (M57627);
- Vascular endothelial growth factor precursor (M32977, M27281);
- Protective factor against cell death 1 (D15057);
- Zinc-finger DNA-binding protein (D45132);
- Bcl2 homologous antagonist (U23765;
- U16811;
- X84213);
- 3′5′-cAMP phosphodiesterase HPDE4A6 (U18087);
- Xeroderma pigmentosum group D complementing protein (X52221);
- Endothelin receptor type A (L06622),
- Epithelial discoidin domain receptor 1 precursor(X74979);
- Tyk2 non-receptor protein tyrosine kinase (X54637);
- Ets-associated protein (U11732);
- Platelet-derived growth factor A subunit precursor (X06374);
- FAN protein (X96586);
- Protein-tyrosine phosphatase γ precursor (L09247);
- EB1 protein (U24166);
- Ras-associated protein RAP-1A (M22995);
- Myelin-bonded oligodendrocytic basic protein (D28113);
- Myelin basic protein (M13577);
- Brain-derived neurotrophic factor (U12140);
- Gamma-aminobutyric acid (GABA) receptor β-1 subunit precursor (X14767);
- 23 k-Da highly basic protein (X56932);
- phosphatidylinositol-4-phosphate-5-kinase type III (S78798+U14957);
- Recoverin (S43855),
- HLA class histocompatibility antigen C-4α subunit(M11886);
- P21-activated kinase α (U24152);
- Brain-specific tubulin α1 subunit (K00558);
- Ras-associated protein RAB-11B (X79780);
- Bone morphogenetic protein 3 (M22491);
- Apoptosis regulator bcl2 (M14745);
- Xenoderma pigmentosum group B complementing protein (M31899);
- Acidic fibroblast growth factor (X65778+X51943+M13361);
- Neural cell adhesion molecule phosphatidylinositol-linked isoform precursor (X16841;
- S71824);
- Bcl2 and p53 linked protein Bbp (U58334);
- Induced myeloid leukemia cell differentiation protein MCL-1 (L08246);
- CD59 glycoprotein precursor (M334671);
- Neurotrophin-4 (M86528+S41522+S41540+S41541);
- and
- diagnosing whether or not the subject suffers from schizophrenia by using a quantitative value of said at least one nucleic acid.
Dependencies are inferred from the claim text.