Arrangement of nucleic acid sequences and their use
OwnerThomas Cremer, Thomas Ried +3inventors
InventorsThomas Cremer, Thomas Ried, Michael Speicher, Anna Jauch, Peter Lichter
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Abstract
A method of determining the relative number of nucleic acid sequences in test cells which provides for a high resolution during comparative genomic hybridization by keeping all components separate from each other and selecting target nucleic acids which have a high resolution capability for determining genomic imbalances in the test cells and which facilitate a screening of the test cells for over- or under-expression of individual genes.
Claims20
An analytical element for analyzing genomic variations by comparative genomic hybridization comprising a supporting matrix having target nucleic acid sequences fixed thereon in a specific geometric arrangement.
A method of making an analytical element for analyzing variations by comparative genomic hybridization comprising selecting target nucleic acids for hybridization and arranging the target nucleic acid sequences on a matrix in a specific geometric arrangement.
Dependencies are inferred from the claim text.