Method for identifying compounds altering higher-order chromatin-dependent chromosome stability
AssigneeBoehringer Ingelheim International GmbH
InventorsThomas Jenuwein, Stephen Rea, Frank Eisenhaber, Donal O'Carroll
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Abstract
A method for identifying compounds that alter higher order chromatin dependent chromosome stability is based on determining the compounds' ability to modify a methyltransferase with Suv39h-like methyltransferase activity. The identified compounds are useful in therapy, in particular the therapy of human cancer and for contraception.
Claims17
A method for identifying a compound that alters higher order chromatin dependent chromosome stability in mitosis and meiosis, said method comprising incubating a substrate for a methyltransferase, in the presence of a methyl donor, with a methyltransferase with Suv39h-like methyltransferase activity, in the presence or absence of a test compound and determining whether the compound modulates the methyltransferase activity.
An antibody that specifically recognises methylated lysine 9 in histone H3.
Dependencies are inferred from the claim text.