Fluorescent compounds
OwnerPhilip John Livingston Bell, Peter Karusoinventors
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Abstract
Fluorescent dye compounds of formula (I) are disclosed. These compounds are useful as they interact with organic compounds in a manner such that excitation with certain wavelengths of light results in fluorescent emmission. Detection and/or monitoring of the fluorescence provides a means for the detection or quantification of organic compounds when bound to these fluorescent dye compounds. Formula (I), wherein: each of R, R′ and R″ is a hydrogen atom, halogen atom or a straight or branched chain (C1-20alkyl, alkenyl or alkynyl group optionally substituted with one or more halogen, hydroxy and/or oxy group: rings A, B and C optionally include one or more double bonds; rings B and C are optionally substituted with one or more halogen atoms.
Claims23
A compound according to formula (I):
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- wherein:
- each of R, R′ and R″ is a hydrogen atom, halogen atom or a straight or branched chain C1-20 alkyl, alkenyl or alkynyl group optionally substituted with one or more halogen, hydroxy and/or oxy group;
- rings A, B and C optionally include one or more double bonds;
- rings B and C are optionally substituted with one or more halogen atoms, including tautomers of formula (I), and
- the compound is capable of interacting with an organic compound and when interacting with the organic compound, the compound emits fluorescence after excitation at a broad range of wavelengths.
A compound as claimed in 3 wherein R is —C(OH)CHC(O)(CH)6CH3, R′ is —CH2OH and R′ is ′Me being the compound 5,6-dihydro-3-[(1Z, 4E, 6E, 8E)-1-hydroxy-3 -oxo-1,4,6,8-decatetraenyl]-6-hydroxymethyl-9a-methyl-2H-furo[3,2-g][2]benzopyran-2-9(9aH)-dione according to formula (Ic), including tautomers thereof:
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A compound according to formula (I):
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- wherein each of R, R′ and R″ is a hydrogen atom, halogen atom or a straight or branched chain C1-20 alkyl, alkenyl or alkynyl group optionally substituted with one or more halogen, hydroxy and/or oxy groups;
- ring A, B and C are optionally substituted with one or more halogen atoms;
- and
- rings A, B and C optionally include one or more double bonds;
- with the proviso that:
- (i) R≠—C(OH)CHC(O)(CH)6C(Et)(Me) when R′=—CH2OH, R″=Me, ring A includes a double bond between C3 and C3a;
- ring B includes a double bond between C4 and C4a;
- and ring C includes a double bond between C8 and C8a;
- (ii) R≠—C(OH)CHC(O)(CH)6C(Et)(Me) when R′=Me, R″=Me, ring A includes a double bond between C3 and C3a;
- ring B includes a double bond between C4 and C4a;
- and ring C includes a double bond between C8 and C8a;
- (iii) R≠—C(OH)CHC(O)(CH)6C(Et)(Me) when R′=Me, R″=Me, ring A includes a double bond between C3 and C3a;
- ring B includes a double bond between C4 and C4a;
- and ring C includes a double bond between C8 and C8a and C5 and C6;
- (iv) R≠—C(O)(CH)4Me when R′=-n-propyl, R″=Me, ring A includes a double bond between C3 and C3a;
- ring B includes a double bond between C4 and C4a;
- and ring C includes a double bond between C8 and C8a and C5 and C6;
- (v) R≠—C(O)(CH)6Me when R′=-n-propyl, R″=Me, ring A includes a double bond between C3 and C3a;
- ring B includes a double bond between C4 and C4a;
- and ring C includes a double bond between C8 and C8a and C5 and C6;
- (vi) R≠—C(O)(CH)5Me when R′=—(CH)2Me, R″=Me, ring A includes a double bond between C3 and C3a;
- ring B includes a double bond between C4 and C4a;
- and ring C includes a double bond between C8 and C8a and C5 and C6;
- (vii) R≠—C(O)(CH)6Me when R′=—(CH)2Me, R″=Me, ring A includes a double bond between C3 and C3a;
- ring B includes a double bond between C4 and C4a;
- and ring C includes a double bond between C8 and C8a and C5 and C6;
- (viii) R≠—(CH)2C(Me)CHC(Me)(Et) when R′=—Ac, R″=Me, C4=Cl, ring A includes a double bond between C3 and C3a;
- ring B includes a double bond between C4 and C4a;
- and ring C includes a double bond between C8 and C8a and C5 and C6;
- (ix) R≠—(CH)2C(Me)CHC(Me)(Et) when R′=—Ac, R″=Me, ring A includes a double bond between C3 and C3a;
- ring B includes a double bond between C4 and C4a;
- and ring C includes a double bond between C8 and C8a and C5 and C6;
- (x) R≠—(CH)2C(Me)CH-i-Pr when R′=—Ac, R″=Me, ring A includes a double bond between C3 and C3a;
- ring B includes a double bond between C4 and C4a;
- and ring C includes a double bond between C8 and C8a and C5 and C6;
- (xi) R≠—C(O)(CH)4Me when R′=—(CH)2Me, R″=Me, ring A includes a double bond between C3 and C3a;
- ring B includes a double bond between C4 and C4a;
- and ring C includes a double bond between C8 and C8a and C5 and C6;
- (xii) R≠—C(O)(CH)4Me when R′=-n-Pr, R″=Me, ring A does not include a double bond;
- and rings B and C include double bonds between C8a and C4a and C5 and C6;
- (xiii) R≠—C(O)(CH)4Me when R′=-n-Pr, R″=Me, ring A, B and C do not include double bonds;
- (xiv) R≠—C(O)(CH)6Me when R′=—(CH)2Me, R″=Me, ring A does not include a double bond;
- and rings B and C include double bonds between C8a and C4a and C5 and C6;
- (xv) R≠—C(O)(CH)4Me when R′=—C(CH2)(Me), R″=Me, ring A does not include a double bond;
- and rings B and C include double bonds between C8a and C4a and C5 and C6;
- (xvi) R≠—C(O)(CH)4Me when R′=—(CH)2Me, R″=Me, ring A does not include a double bond;
- and rings B and C include double bonds between C8a and C4a and C5 and C6, including tautomers thereof.
Dependencies are inferred from the claim text.