Genotyping the human UDP-glucuronosyl transferase 1 (UGT1) gene
AssigneeDNA Sciences Laboratories, Inc.
InventorsLaura Penny, Margaret Galvin
Life of this patent
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Abstract
Genetic polymorphisms are identified in the human UGT1 gene that alter UGT1-dependent drug metabolism. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for UGT1 substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.
Claims10
An isolated nucleic acid molecule comprising a UGT1 sequence polymorphism of SEQ ID NOS:
- 87-124, as part of other than a naturally occurring chromosome.
A nucleic acid probe for detection of UGT1 locus polymorphisms, comprising a polymorphic sequence of SEQ ID NOS:87-124.
An array of oligonucleotides comprising:
- two or more probes for detection of UGT1 locus polymorphisms, said probes comprising at least one form of a polymorphic sequences of SEQ ID NOS:87-124.
A method for detecting in an individual a polymorphism in UGT1 metabolism of a substrate, the method comprising:
- analyzing the genome of said individual for the presence of at least one UGT1 polymorphism of SEQ ID NOS:87-124;
- wherein the presence of said predisposing polymorphism is indicative of an alteration in UGT1 expression or activity.
Dependencies are inferred from the claim text.