G protein coupled receptor
OwnerEckhard Bender, Arjan Buist +3inventors
InventorsEckhard Bender, Arjan Buist, Martine Ercken, Walter Herman Maria Louis Luyten, Mirek Jurzak
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Abstract
The invention provides nucleic acid encoding a G protein coupled receptor (adenine binding GPCR) with specificity for adenine, isolated adenine binding GPCR, assay and treatment methods utilising the same.
Claims23
An isolated nucleic acid sequence encoding the polypeptide of SEQ ID NO:
- 2 or SEQ ID NO:
- 4.
An isolated nucleic acid sequence comprising SEQ ID NO:
- 1, SEQ ID NO:
- 3, SEQ ID NO:
- 5, SEQ ID NO:
- 6 SEQ ID NO:
- 7, SEQ ID NO:
- 8 or SEQ ID NO:
- 9.
An isolated nucleic acid sequence having at least 50% sequence identity to SEQ ID NO:
- 1, SEQ ID NO:
- 3, SEQ ID NO:
- 5, SEQ ID NO:
- 6 SEQ ID NO:
- 7, SEQ ID NO:
- 8 or SEQ ID NO:
- 9.
An isolated polypeptide having the sequence of SEQ ID NO:
- 2 or SEQ ID NO:
- 4.
An isolated polypeptide having at least 50% sequence identity to the polypeptide of SEQ ID NO:
- 2 or SEQ ID NO:
- 4.
Adenine for use in a method of treatment in a human or animal body.
Use of adenine in the preparation of a medicament for the treatment of a disease, the pathology of which is associated with action at purine receptors.
Dependencies are inferred from the claim text.