Use of SNPs of MCH-R for identifying genetic disorders in maintaining the normal body weight
OwnerJohannes Hebebrand, Anke Hinney +3inventors
InventorsJohannes Hebebrand, Anke Hinney, Anne-Kathrin Wermter, Frank Geller, Andreas Ziegler
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Abstract
A process for identification of a human individual's disposition for a genetic disorder in maintaining body weight is disclosed.
Claims12
A process for identification of a disposition for a genetic disorder in maintaining normal body weight, comprising steps a], b] and d]:
- a] isolating polynucleotides from at least one cell of an individual, wherein the polynucleotides comprise an MCH-receptor gene from that individual's genome,
- b] detecting the presence or absence of at least one SNP of the MCH-receptor gene, including the non-coding regions upstream and downstream within a range of 10 Kb from beginning and end of the coding regions, in the polynucleotides from step a], wherein the SNP correlates with the genetic disorder in maintaining the normal body weight, and
- d] determining the disposition for the genetic disorder in maintaining normal body weight by analysis of the results from step b].
A diagnostic kit for identifying a disposition for a genetic disorder in maintaining normal body weight, comprising DNA or RNA probes for detection of one or several SNPs of the MCH-receptor gene.
A polynucleotide of at least 12 nucleotides, comprising a portion of a MCH-receptor gene sequence wherein at position 100365 of NCBI Z86090 the C is replaced by a T (SNP133073).
Dependencies are inferred from the claim text.