Interferon-alpha induced genes
OwnerJean-Francois Meritet, Michel Dron +1inventors
InventorsJean-Francois Meritet, Michel Dron, Michael Gerard Tovey
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Abstract
The present disclosure relates to identification of previously known genes as being genes upregulated by interferon-α administration, in particular the human genes corresponding to the cDNA sequence in GenBank designated g4758303, g5453897, g4505186, g2366751, g33917, g4504962, g3978516, g5924396, g4505656, g1504007, g3702446, g4001802, g292289, g4557226, g4507646 and g4507170. Determination of expression products of these genes is proposed as having utility in predicting responsiveness to treatment with interferon-α and other interferons which act at the Type 1 interferon receptor.
Claims7
A method of predicting responsiveness of a patient to treatment with a Type 1 interferon, which comprises determining the level of one or more proteins selected from the proteins defined by the sequences set forth in SEQ ID NO:
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- 32 and naturally-occurring variants thereof, or one or more of the corresponding mRNAs, in a cell sample from said patient, wherein said sample is obtained from said patient following administration of a Type 1 interferon or is treated prior to said determining with a Type 1 interferon in vitro.
Dependencies are inferred from the claim text.