Chemotherapeutant screening method
OwnerPeter Krammer, Soren Eichhorst +2inventors
InventorsPeter Krammer, Soren Eichhorst, Min Li-Weber, Martina Muller-Schilling
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Abstract
Disclosed is a method for determining whether a test compound is effective for a chemotherapy. The inventive method comprises the following steps: a) a DNA sequence is provided, whereby said sequence comprises site AP-1 represented in FIG. 5A as a constituent of a promoter, preferably promoter CD95L, which is functionally linked to a reporter gene or the CD95L gene, b) the DNA sequence a) is brought into contact with the test compound in a cellular assay, and c) activation of the promoter is determined, said activation indicating that the test compound is effective for a chemotherapy.
Claims8
A method of studying whether a test compound is effective for a chemotherapy, wherein the method comprises the steps of:
- a) providing a DNA sequence which comprises the AP-1 site shown in FIG. 5A as a constituent of a promoter functionally linked with a reporter gene or CD95L gene;
- b) contacting the DNA sequence from a) with the test compound in a cellular assay;
- and
- c) determining the activation of the promoter, said activation indicating that the test compound is effective for a chemotherapy.
Dependencies are inferred from the claim text.