Novel human rna helicase, helicain
OwnerTakashi Sugihara, Renu Wadwainventors
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Abstract
Novel RNA helicase genes of human origin, Helicain A, B, and C, were isolated. The expression of these genes was significantly elevated in thyroid gland and cancer cells. Helicain proteins and genes encoding them can be used as tools for examination and development of pharmaceuticals for diseases, such as cancer.
Claims23
A DNA selected from the group consisting of:
- (a) a DNA encoding a protein comprising the amino acid sequence of SEQ ID NO:
- 2, 4 or 6;
- and
- (b) a DNA comprising the coding region of the nucleotide sequence of SEQ ID NO:
- 1, 3 or 5.
A DNA encoding a protein having the activity to bind with Tesmin protein selected from the group consisting of:
- (a) a DNA encoding a protein comprising the amino acid sequence of SEQ ID NO:
- 2, 4 or 6 in which one or more amino acids are substituted, deleted, inserted, and/or added;
- and
- (b) a DNA hybridizing with a DNA consisting of the nucleotide sequence of SEQ ID NO:
- 1, 3 or 5.
A DNA encoding a protein having RNA helicase activity selected from the group consisting of:
- (a) a DNA encoding a protein comprising the amino acid sequence of SEQ ID NO:
- 4 or 6 in which one or more amino acids are substituted, deleted, inserted, and/or added;
- and
- (b) a DNA hybridizing with a DNA consisting of the nucleotide sequence of SEQ ID NO:
- 3 or 5.
A polynucleotide complementary to either a DNA that comprises the nucleotide sequence of SEQ ID NO:
- 1, 3 or 5, or its complementary strand, wherein the polynucleotide comprises at least 15 nucleotides.
Dependencies are inferred from the claim text.