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AssigneeUniversiteit Maastricht
InventorsGuillaume Johannes J. M. van Eijs, Guus Hateboer, Menzo Jans E. Havenga
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The present invention discloses novel smooth muscle cell specific promoters and uses thereof. The promoters are suited for providing nucleic acid of interest with the capability of expressing specifically in a contractile smooth muscle cell, preferably a vascular contractile smooth muscle cell and/or a visceral contractile smooth muscle cell. One example of such a promoter is a smoothelin gene promoter. For gene therapy purposes said smoothelin gene promoter is preferably derived from a human. A promoter of the invention may be incorporated into nucleic acid delivery vehicle. The nucleic acid delivery vehicle preferably comprises a virus-like particle such as an adenovirus particle, an adeno-associated virus particle or a retrovirus particle.
A nucleic acid delivery vehicle comprising nucleic acid of interest capable of expressing specifically in a contractile smooth muscle cell.
A cell provided with nucleic acid of interest capable of expressing specifically in a contractile smooth muscle cell.
A promoter of a smoothelin gene, or a functional part, derivative and/or analogue thereof.
Use of a promoter, or a functional part, derivative and/or analogue thereof of a smoothelin gene, for providing a nucleic acid of interest with the capacity to express specifically in a contractile smooth muscle cell.
A nucleic acid as depicted in FIG. 6-14, or a functional equivalent thereof.
Dependencies are inferred from the claim text.