Chemical compounds
OwnerCarl John Cresswell, Adam Jeston Dudleyinventors
Life of this patent
Estimating the term…
Abstract
This invention relates to polymorphisms in the human MCT-1 gene. The invention also relates to methods and materials for analysing allelic variation in the MCT-1 gene, and to the use of MCT-1 polymorphism in treatment of diseases with MCT-1 transportable drugs.
Claims12
A method for the diagnosis of a polymorphism in MCT-1 in a human, which method comprises determining the sequence of the nucleic acid of the human at at least one polymorphic position selected from one or more of the following positions:
- positions 1450 and 2461 in the polynucleotide sequence of the MCT-1 gene as defined by the position in SEQ ID NO:
- 13.
A method according to claim one in which the polymorphisms are further defined as follows:
- at position 1450 is presence of A and/orG;
- and
- at position 2461 is the presence of A and/or G.
A polynucleotide comprising at least 20 bases of the human MCT-1 gene and comprising an allelic variant selected from any one of the following:
- 8 Position in SEQ variant ID NO 13 G 1450 G 2461
A method of treating a human in need of treatment with a drug transportable by MCT-1 in which the method comprises:
- i) diagnosis of a polymorphism in MCT-1 in the human, which diagnosis comprises determining the sequence of the human at one or more of the following positions:
- positions 1450, 1482 and 2461 in the sequence of the MCT-1 polynucleotide as defined by the position in SEQ ID NO:
- 13;
- and
- at position 490 of human MCT-1 polypeptide as defined by the position in SEQ ID NO 14;
- and
- ii) administering an effective amount of the drug.
Dependencies are inferred from the claim text.