Injectable depot composition
OwnerGuohua Chen, Paul R. Houston +3inventors
InventorsGuohua Chen, Paul R. Houston, Jeremy Corwin Wright, Jonas Fransson, Birger Hjertman
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Abstract
Gel compositions are provided that can be utilized as carriers for beneficial agents when injected into a subject and which can provide sustained release of the beneficial agent over time. In particular, gel compositions containing an agent that renders the composition thixotropic to facilitate injection of the gel into a subject with minimal discomfort to the subject are described.
Claims25
A composition comprising a lactic acid-based polymer;
- a solvent that forms a polymer solution with said polymer;
- an amount of an agent mixed with the polymer solution effective to form a thixotropic composition, said agent being selected from the group consisting essentially of lower alkanols and said amount being less than 15 weight percent of the combined weight of the solvent and the agent;
- and a beneficial agent.
A composition comprising polylactic acid polymer;
- a solvent that forms a polymer solution with said polymer;
- an amount of an agent mixed with the polymer solution effective to form a thixotropic composition, said agent being selected from the group consisting essentially of lower alkanols and said amount being less than 15 weight percent of the combined weight of the solvent and the agent;
- a beneficial agent.
A composition comprising a lactic acid-based polymer formed as a copolymer of lactic acid and glycolic acid;
- a solvent that forms a polymer solution with said polymer;
- an amount of an agent mixed with the polymer solution effective to form a thixotropic composition, said agent being selected from the group consisting essentially of lower alkanols and said amount being less than 15 weight percent of the combined weight of the solvent and the agent;
- a beneficial agent.
Dependencies are inferred from the claim text.