Pharmaceutical suspension for oral administration
OwnerGuang Wei Lu, Po-Chang Chianginventors
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Abstract
A pharmaceutical composition suitable for oral administration is provided, the composition comprising an aqueous medium having suspended therein a solid substance of low water solubility in particulate form, and further comprising a suspending agent and at least one pharmaceutically acceptable water-soluble or swellable nonsurfactant polymer, the total amount of all such polymers present being ineffective to (a) increase viscosity of the composition to a degree that significantly impairs pourability, or (b) significantly increase rate of sedimentation or phase separation, of the composition. The composition has improved mouth feel.
Claims20
A pharmaceutical composition suitable for oral administration, the composition comprising an aqueous medium having suspended therein a solid substance of low water solubility in particulate form, and further comprising a suspending agent and at least one pharmaceutically acceptable water-soluble or swellable nonsurfactant polymer, the total amount of all such polymers present being less than 1% by weight of the composition.
A process for preparing a pharmaceutical composition, the process comprising a step of dispersing a solid particulate substance of low water solubility in an aqueous liquid to form a dispersion, a step of adding at least one water-soluble or swellable nonsurfactant polymer to the aqueous liquid, and a step of adding a suspending agent to the dispersion with mixing to form a suspension, wherein the suspending agent is added after addition of the polymer, and wherein the total amount of such polymer added is less than 1% by weight of the composition.
Dependencies are inferred from the claim text.