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OwnerRichard Liggins, Larry Murphy +1inventors
InventorsRichard Liggins, Larry Murphy, Dechi Guan
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Anhydrous formulations are formed of a diblock copolymer (X-Y) having a hydrophilic block X comprising residues of monomer x, and a hydrophobic block Y comprising residues of monomer y; an additive selected from a polymer and an organic solvent, where the solvent is water-miscible and biocompatible, and the polymer is hydrophobic or hydrophilic and comprises residues of monomers x and/or y, the polymer optionally having a molecular weight that is less than the molecular weight of the diblock copolymer; and a drug. Upon admixture with water, the anhydrous formulations form drug delivery vehicles, preferably in micellar form. The inclusion of polymer and/or organic solvent provides for the formation of micelles at an enhanced rate, and/or provides the formation of micelles having an enhanced ability to incorporate drug(s), and/or provides the formation of micelles having advantageous physical characteristics, e.g., advantageous viscosity and/or melting point.
A composition comprising:
A composition comprising:
A composition comprising:
A composition comprising
A composition comprising
A composition comprising
A composition formed by
A composition formed by
A composition formed by
A method of forming a composition comprising
A composition comprising solid hydrophobic drug and solid micelle-forming biocompatible diblock copolymer (X-Y) having a hydrophilic block X comprising residues of monomer x and a hydrophobic block Y comprising residues of monomer y.
A low organic solvent content composition comprising hydrophobic drug and micelle-forming biocompatible diblock copolymer (X-Y) having a hydrophilic block X comprising residues of monomer x and a hydrophobic block Y comprising residues of monomer y, wherein the solvent content of the composition is less than 1000 ppm.
A fluid composition comprising hydrophobic drug and micelle-forming biocompatible diblock copolymer (X-Y) having a hydrophilic block X comprising residues of monomer x and a hydrophobic block Y comprising residues of monomer y.
A composition comprising:
A composition comprising a micelle-forming biocompatible diblock copolymer (X-Y) having a hydrophilic block X comprising residues of monomer x, and a hydrophobic block Y comprising residues of monomer y, wherein X comprises polyether and Y comprises polyester, said composition having an acid value of less than 0.4 μmol/mg acid.
A method for preparing a composition, the method comprising
A method for preparing a composition, the method comprising
A method of forming a composition comprising sequentially combining
Dependencies are inferred from the claim text.