Controlled release sulfonylurea formulation
OwnerChih Ming Chen, Joseph Chou +1inventors
InventorsChih Ming Chen, Joseph Chou, David Wong
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Abstract
Disclosed in a controlled release sulfonylurea formulation. In certain embodiments, the invention comprises: (a) a core comprising: (i) a sulfonylurea or a pharmaceutically acceptable salt thereof; (ii) a pharmaceutically acceptable polymer; (b) a membrane surrounding the core which is permeable to the sulfonylurea and gastrointestinal fluid, wherein said dosage form provides a mean time to maximum plasma concentration (Tmax) of said sulfonylurea.
Claims31
A controlled release oral dosage form comprising:
- (a) a core comprising:
- (i) a sulfonylurea or a pharmaceutically acceptable salt thereof;
- (ii) a pharmaceutically acceptable polymer;
- (b) a membrane surrounding the core which is permeable to the sulfonylurea and gastrointestinal fluid;
- said dosage form being suitable for providing once-a-day oral administration of the sulfonylurea.
A method for lowering blood glucose levels in human patients needing treatment for non-insulin-dependent diabetes mellitus (NIDDM), comprising orally administering to human patients on a once-a-day basis a dose of controlled release dosage form comprising:
- (a) a core comprising:
- (i) a sulfonylurea or a pharmaceutically acceptable salt thereof;
- (ii) a pharmaceutically acceptable polymer;
- (b) a membrane surrounding the core which is permeable to the sulfonylurea and gastrointestinal fluid;
- said dosage form being suitable for providing once-a-day oral administration of the sulfonylurea.
A controlled release oral dosage form comprising:
- (a) a core comprising:
- (i) an agent consisting essentially of a sulfonylurea or a pharmaceutically acceptable salt thereof;
- (ii) a pharmaceutically acceptable polymer;
- and
- (b) a membrane surrounding the core which is permeable to the sulfonylurea and gastrointestinal fluid;
- said dosage form being suitable for providing once-a-day oral administration of the sulfonylurea.
Dependencies are inferred from the claim text.