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US 2003/0157162 A1Published application
Liposome-encapsulated opioid analgesics
OwnerLisa A. Krugner-Higby, Timothy D. Heath +1inventors
InventorsLisa A. Krugner-Higby, Timothy D. Heath, Lesley J. Smith
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Abstract
Liposome-encapsulated opioid formulations and methods of use for long-term analgesic activity in animals are provided.
Claims9
A liposome-encapsulated opioid formulation comprising an opioid compound encapsulated in a liposome by a rehydration/dehydration method that produces liposome-encapsulated opioid so that said liposome-encapsulated opioid has long-term analgesic activity in an animal.
A method for producing liposome-encapsulated opioid comprising:
- a) suspending opioid in a buffer to form an oxymorphone-buffer mixture;
- b) overlaying the opioid-buffer mixture onto a film of lipid;
- c) sonicating the opioid-buffer mixture and the lipid to form liposome;
- d) freezing the liposomes by mixing the liposomes over a slurry of dry ice and isopropanol;
- and
- e) freeze-drying the liposomes for storage in a freezer until the liposome mixture is rehydrated in sterile water.
3 more elements
A method for producing liposome-encapsulated opioid comprising:
- a) suspending opioid in a buffer to form an oxymorphone-buffer mixture;
- b) overlaying the opioid-buffer mixture onto a film of lipid;
- c) freezing the opioid-buffer mixture and film of lipid;
- and
- d) thawing the mixture to generate liposomes.
2 more elements
Dependencies are inferred from the claim text.