Compositions and methods for treating inflammatory conditions utilizing protein or polysaccharide containing anti-microtubule agents
AssigneeAngiotech Pharmaceuticals, Inc.
InventorsWilliam L. Hunter, David M. Gravett, Richard T. Liggins, Philip M. Toleikis
Life of this patent
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Abstract
Disclosed herein are compositions and methods for treating a variety of inflammatory conditions (e.g., inflammatory arthritis, adhesions, tumor excision sites, and fibroproliferative diseases of the eye). For example, there is provided a composition comprising a protein or polysaccharide containing dispersed (e.g., in micelle or liposome form) anti-microtubule agent, which may be formulated for administration to a patient in need thereof.
Claims125
A composition comprising a polypeptide or a polysaccharide and an anti-microtubule agent dispersed by a carrier, the anti-microtubule agent being dispersed independent of the polypeptide or polysaccharide.
A composition, comprising:
- (a) an anti-microtubule agent;
- (b) a carrier that enhances the dispersability of the anti-microtubule agent in an aqueous medium;
- and
- (c) at least one of a polypeptide or a polysaccharide.
A process for forming a composition, the process comprising:
- (a) contacting an anti-microtubule agent with a carrier to form an anti-microtubule agent dispersed by a carrier;
- and
- (b) combining (a) with a polypeptide or a polysaccharide, thereby forming the composition.
A process for forming a composition, the process comprising:
- (a) combining a polypeptide or a polysaccharide with a carrier in an aqueous medium;
- and
- (b) adding an anti-microtubule agent to (a), thereby forming a composition wherein the anti-microtubule agent is dispersed by the carrier.
A kit, comprising:
- (a) an anti-microtubule agent dispersed by a carrier;
- and
- (b) a polysaccharide or a polypeptide.
A composition, comprising an anti-microtubule agent dispersed by a carrier and hyaluronic acid or a derivative thereof, the composition being in sterile form.
Dependencies are inferred from the claim text.