Vaccine for modulating between T1 and T2 immune responses
AssigneeBiomira, Inc.
InventorsWladyslaw A. Budzynski, R. Rao Koganty, Mark J. Krantz, B. Michael Longenecker
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Abstract
The present invention provides liposomal vaccines containing immunogenic lipopeptides that are capable of modulating the humoral and cellular immune responses in vivo.
Claims81
A liposomal composition comprising at least one liposome that comprises at least one monolipopeptide and at least one dilipopeptide.
A liposomal formulation comprising a first liposomal composition and a second liposomal composition, wherein the first liposomal composition comprises a monolipopeptide and wherein the second liposomal composition comprises a dilipopeptide.
A method for modulating an immune response comprising administering to a patient an effective amount of at least one monolipopeptide and at least one dilipopeptide.
A method of modulating an immune response, comprising simultaneously administering a formulation comprising a liposomally-bound monolipopeptide and a formulation comprising a liposomally-bound dilipopeptide.
A method of modulating between a cellular and humoral immune response, comprising first administering a formulation comprising a liposomally-bound monolipopeptide and then subsequently administering a formulation comprising a liposomally-bound dilipopeptide.
A method of modulating between a cellular and humoral immune response, comprising first administering a formulation comprising a liposomally-bound dilipopeptide and then subsequently administering a formulation comprising a liposomally-bound monolipopeptide.
A method for modulating an immune response comprising administering to an individual at least one liposome which consists essentially of a dilipopeptide.
A method for modulating an immune response comprising administering to an individual at least one liposome which consists of a dilipopeptide.
A method for modulating an immune response comprising administering to an individual at least one liposome which comprises a dilipopeptide.
A MUC I peptide composition comprising one lipid attached to an amino acid of the MUC I peptide.
A tuberculosis peptide composition comprising one lipid attached to an amino acid of the tuberculosis peptide.
A tuberculosis peptide composition comprising two lipids attached to at least one amino acid of the tuberculosis peptide.
A hepatitis B peptide composition comprising one lipid attached to an amino acid of the hepatitis B peptide.
A hepatitis B peptide composition comprising two lipids attached to at least one amino acid of the hepatitis B peptide.
A malaria peptide composition comprising one lipid attached to an amino acid of the malaria peptide.
A malaria peptide composition comprising two lipids attached to at least one amino acid of the malaria peptide.
A peptide selected from the group consisting of SEQ ID NOs 1-4, comprising more than two lipids.
Dependencies are inferred from the claim text.