Compositions for use as penetration promoters in transdermal formulations for highly lipophilic active ingredients
OwnerRalph Lipp, Adrian Funke +1inventors
InventorsRalph Lipp, Adrian Funke, Clemens Guenther
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Abstract
A composition for use as penetration promoter in transdermal formulations for highly lipophilic active ingredients or active ingredient combinations, which comprises at least a first and a second penetration promoter, where the first penetration promoter is a monohydric or polyhydric alcohol, and the second penetration promoter is a saturated or unsaturated fatty acid having 8 to 18 carbon atoms or an ester or derivative thereof.
Claims14
A transdermal formulation comprising a highly lipophilic active ingredient or active ingredient combination with a log P≧4 and a penetration promoting composition which comprises at least a first and a second penetration promoter, where the first penetration promoter is a monohydric or polyhydric alcohol, and the second penetration promoter is a saturated or unsaturated fatty acid having 8 to 18 carbon atoms or an ester or derivative thereof and wherein the two penetration promoters are present in a ratio of from 2 to 15 parts by weight of first penetration promoter to 1 part by weight of second penetration promoter.
A transdermal formulation as claimed in any of preceding claims, which is a transdermal system.
A transdermal formulation comprising an antiestrogen and a penetration promoting composition which comprises at least a first and a second penetration promoter, where the first penetration promoter is a monohydric or polyhydric alcohol, and the second penetration promoter is a saturated or unsaturated fatty acid having 8 to 18 carbon atoms or an ester or derivative thereof and wherein the two penetration promoters are present in a ratio of from 2 to 15 parts by weight of first penetration promoter to 1 part by weight of second penetration promoter.
Dependencies are inferred from the claim text.