Compositions containing hydroxy aromatic aldehydes and their use in treatments
OwnerBryan Fuller, Brian Keith Pilcherinventors
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Abstract
Disclosed are pharmaceutical and cosmetic compositions containing hydroxy aromatic aldehyde compounds. The disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. The disclosed compositions are also useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.
Claims41
A composition comprising a pharmaceutically acceptable topical carrier and a compound of Formula I, II or III:
- 2
- wherein
- R1 is a carbon-carbon single bond, or a straight chain or branched chain alkylene;
- R2 is a carbon-oxygen single bond, or a straight chain or branched chain alkylene;
- each R3 is independently alkyl, or in the case of the compounds of Formula II, the two R3s together with the atoms to which they are attached form a heterocycloalkyl;
- and
- each R4 is independently selected from the group consisting of hydrogen, hydroxyl, alkyl, substituted alkyl, alkcycloalkyl, cycloalkyl, alkoxy, alkcycloalkoxy, cycloalkoxy, acyl, acyloxy and halogen.
A systemic pharmaceutical composition comprising a systemically suitable pharmaceutically acceptable carrier and a pharmaceutically effective amount of a compound of Formula I, II or III:
- 4
- wherein
- R1 is a carbon-carbon single bond or a straight chain or branched chain alkylene;
- R2 is a carbon-oxygen single bond, or a straight chain or branched chain alkylene;
- each R3 is independently alkyl, or in the case of the compounds of Formula II, the two R3s together with the atoms to which they are attached form a heterocycloalkyl;
- and
- each R4 is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkcycloalkyl, cycloalkyl, alkoxy, alkcycloalkoxy, cycloalkoxy, acyl, acyloxy and halogen.
Dependencies are inferred from the claim text.