Methods for inhibiting the production of TSST-1
AssigneeKimberly-Clark Worldwide, Inc.
InventorsRae Ellen Syverson, Richard A. Proctor
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Abstract
The present invention relates to inhibiting the production of TSST-1 using absorbent products and non-absorbent products comprising an additive, as well as methods for inhibiting such production. The absorbent and non-absorbent products or articles include an effective amount of an inhibitory compound, such as thiolactomycin or thiomalonate to substantially inhibit the production of TSST-1 or exoprotein by Gram positive bacteria.
Claims20
A method of inhibiting the production of TSST-1 from Gram positive bacteria comprising exposing the Gram positive bacteria to an effective amount of a first active ingredient having the general formula:
- 14
- wherein:
- R300 is, when present, selected from hydrogen and substituted or unsubstituted alkyl;
- R301 is selected from the group consisting of hydrogen, a monovalent, saturated or unsaturated, substituted or unsubstituted hydrocarbyl moiety, and when R300 is not present, a substituted or unsubstituted hydrocarbenyl moiety;
- R302 is selected from hydrogen, substituted or unsubstituted alkyl;
- and, R303 is selected from hydrogen, hydroxy, and the first active ingredient is effective in inhibiting the production of TSST-1 from Gram positive bacteria.
The method as set forth in claim 8 wherein the second active ingredient is selected from the group consisting of 2-phenylethanol, benzyl alcohol, trans-cinnamic acid, 4-hydroxybenzoic acid, methyl ester, 2-hydroxybenzoic acid, 2-hydroxybenzamide, acetyl tyrosine, 3,4,5-trihydroxybenzoic acid, lauryl 3,4,5-trihydroxybenzoate, phenoxyethanol, 4-hydroxy-3-methoxybenzoic acid, para-aminobenzoic acid, and acetaminophen.
Dependencies are inferred from the claim text.