# US 2003/0157137 A1 · Emulsified skin care composition containing salicylic acid, lanolin oil, and propylene glycol

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2003/0157137 A1
- Document ID: US20030157137A1
- Status: Published application
- Kind: A1
- Application number: 10/322,811
- Filed: 2002-12-19
- Published: 2003-08-21
- Earliest claimed: 2001-12-19
- Assignees: Alwyn Company, Inc.
- Inventors: Elliott Farber
- Web page: https://patentgrep.com/patent/US20030157137A1

## CPC

- A61K 8/062: {Oil-in-water emulsions}
- A61K 8/368: with carboxyl groups directly bound to carbon atoms of aromatic rings
- A61K 8/39: Derivatives containing from 2 to 10 oxyalkylene groups
- A61K 8/67: Vitamins
- A61K 8/671: {Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal}
- A61K 8/86: Polyethers
- A61K 8/925: {of animal origin}
- A61Q 5/006: {Antidandruff preparations}
- A61Q 19/00: Preparations for care of the skin
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

A composition comprising an oil-in-water emulsion for skin care containing salicylic acid or another hydroxy acid, and propylene glycol to prevent formation of crystals of the hydroxy acid. The composition includes, as an emulsifier, at least one nonionic polyoxyethylene ether with a HLB of about 15 to about 17; in some embodiments, another nonionic polyoxyethylene ether with a HLB of 10 to 12 is also included. The composition also includes lanolin oil and a complex comprising Vitamin A and Vitamin D3. Other ingredients, such as a hydrophilic carbohydrate-containing polymer or a quaternary ammonium-containing polymer, can be included. Still other ingredients, such as preservatives, chelators, herbal extracts, allantoin and fragrance, can be included. Another aspect of the invention is a method of use of a composition according to the present invention in treating dermatological or systemic inflammatory conditions such as psoriasis, seborrheic dermatitis, and dandruff.

## Claims

### Claim 1

A skin care composition comprising an oil in-water emulsion, comprising:
(a) water;
(b) salicylic acid in an effective quantity;
(c) lanolin oil in an effective quantity;
(d) a complex comprising Vitamin A and Vitamin D3 in an effective quantity;
(e) an emulsifier component in a quantity sufficient to effectively emulsify oil and water phases, the emulsifier component comprising a nonionic ether surfactant with a HLB of about 12 to about 18; and
(f) a solvent component in an effective quantity, wherein the pH of the composition is from about 2.0 to about 4.0.

### Claim 2 (depends on 1)

The skin care composition of claim 1, wherein the nonionic ether surfactant is selected from the group consisting of ceteareth-2, ceteareth-3, ceteareth-4, ceteareth-5, ceteareth-6, ceteareth-7, ceteareth-8, ceteareth-9, ceteareth-10, ceteareth-11, ceteareth-12, ceteareth-13, ceteareth-14, ceteareth-15, ceteareth-16, ceteareth-17, ceteareth-18, ceteareth-19, ceteareth-20, ceteareth-21, ceteareth-22, ceteareth-23, ceteareth-24, ceteareth-25, ceteareth-26, ceteareth-27, ceteareth-28, ceteareth-29 and ceteareth-30.

### Claim 3 (depends on 1)

The skin care composition of claim 1, wherein the composition further comprises dimethicone.

### Claim 4 (depends on 1)

The skin care composition of claim 1, wherein the composition further comprises at least one of a plant extract and a herbal extract.

### Claim 5 (depends on 1)

The skin care composition of claim 1, wherein the solvent component comprises at least one solvent selected from the group consisting of propylene glycol, ethylene glycol, 1,3-butylene glycol, sorbitol, and glycerol.

### Claim 6 (depends on 1)

The skin care composition of claim 1, wherein the composition further comprises a long-chain fatty acid ester of glycerol selected from the group consisting of glyceryl stearate, glyceryl palmitate, and glyceryl arachidate.

### Claim 7 (depends on 1)

The skin care composition of claim 1, wherein the composition further comprises a lipid-soluble long-chain alcohol component.

### Claim 8 (depends on 7)

The skin care composition of claim 7, wherein the lipid-soluble long-chain alcohol component comprises at least one long-chain lipid-soluble alcohol selected from the group consisting of stearyl alcohol and cetyl alcohol.

### Claim 9 (depends on 1)

The skin care composition of claim 1, wherein the composition further comprises caprylic/capric triglycerides.

### Claim 10 (depends on 1)

The skin care composition of claim 1, wherein the composition further comprises a preservative component.

### Claim 11 (depends on 10)

The composition of claim 10, wherein the preservative component further comprises at least one preservative selected from the group consisting of propylparaben, methylparaben, and 2-methyl-4-isothiazolin-3-one.

### Claim 12 (depends on 1)

The skin care composition of claim 1, wherein the composition further comprises an antioxidant component.

### Claim 13 (depends on 12)

The skin care composition of claim 12, wherein the antioxidant component comprises at least one antioxidant selected from the group consisting of butylated hydroxytoluene, butylated hydroxyanisole, and a complex comprising propyl gallate, propylene glycol, and citric acid.

### Claim 14 (depends on 1)

The skin care composition of claim 1, wherein the composition further comprises a chelator component.

### Claim 15 (depends on 14)

The skin care composition of claim 14, wherein the chelator component is tetrasodium ethyl enediaminetetraacetic acid.

### Claim 16

A skin care composition comprising an oil in-water emulsion comprising:
(a) from about 40.0% to about 80.0% of water;
(b) from about 1.8% to about 3.0% of salicylic acid;
(c) from about 2.0% to about 20.0% of lanolin oil;
(d) from about 0.005% to about 0.50% of a complex comprising Vitamin A and Vitamin D3;
(e) from about 1.0% to about 6.0% of ceteareth-25;
(f) from about 2.0% to about 35.0% of propylene glycol;
(g) from about 0.05% to about 0.50% of tetrasodium ethylenediaminetetraacetic acid;
(h) from about 0.5% to about 5.0% of caprylic/capric triglycerides;
(i) from about 0.5% to about 5.0% of dimethicone;
(j) from about 2.0% to about 12.0% of cetyl alcohol;
(k) from about 1.0% to about 10.0% stearyl alcohol;
(l) from about 1.0% to about 5.0% of glyceryl stearate;
(m) from about 0.1% to about 1.0% of butylated hydroxytoluene;
(n) from about 0.10% to about 0.50% of propylparaben;
(o) from about 0.10% to about 0.50% of methylparaben;
(p) from about 0.005% to about 0.08% of 2-methyl-4-isothiazolin-3-one;
(q) from about 0.10% to about 0.40% of fragrance;
(r) optionally, from about 0.025% to about 2.5% of at least one plant or herbal extract; and
(s) optionally, from about 0.01% to about 1.5% of allantoin.

### Claim 17 (depends on 1)

A method for treating a dermatological or systemic inflammatory condition, comprising the step of applying the skin care composition of claim 1 to the skin of a patient in a therapeutically effective quantity.

### Claim 18 (depends on 17)

The method of claim 17, wherein the dermatological or systemic inflammatory condition is selected from the group consisting of psoriasis, seborrheic dermatitis and dandruff.

### Claim 19 (depends on 17)

The method of claim 17, further comprising the step of administering at least one additional topically or systemically administered agent for the treatment of psoriasis.

### Claim 20

A skin care composition comprising an oil-in-water emulsion comprising:
(a) water;
(b) a hydroxy acid in an effective quantity, the hydroxy acid being selected from the group consisting of α-hydroxy acids, β-hydroxy acids, and multi-hydroxy acids;
(c) lanolin oil in an effective quantity;
(d) a complex comprising Vitamin A and Vitamin D3 in an effective quantity;
(e) an emulsifier component in a quantity sufficient to effectively emulsify oil and water phases, the emulsifier component comprising a nonionic ether surfactant with a HLB of about 12 to about 18;
(f) a solvent component in an effective quantity; and
(g) optionally, allantoin in an effective quantity, wherein the pH of the composition is from about 2.0 to about 4.0.

### Claim 21 (depends on 20)

A method for treating a dermatological or systemic inflammatory condition, comprising the step of applying the skin care composition of claim 20 to the skin of a patient in a therapeutically effective quantity.

### Claim 22 (depends on 21)

The method of claim 21, wherein the dermatological or systemic inflammatory condition is selected from the group consisting of psoriasis, seborrheic dermatitis and dandruff.

### Claim 23 (depends on 21)

The method of claim 21, further comprising the step of administering at least one additional topically or systemically administered agent for the treatment of psoriasis.

### Claim 24

A skin care composition comprising an oil-in-water emulsion, comprising:
(a) water;
(b) salicylic acid in an effective quantity;
(c) lanolin oil in an effective quantity;
(d) a complex comprising Vitamin A and Vitamin D3 in an effective quantity;
(e) an emulsifier component in a quantity sufficient to effectively emulsify oil and water phases, the emulsifier component comprising:
(i) a first nonionic polyoxyethylene ether with a HLB of about 15 to about 17; and
(ii) a second nonionic polyoxyethylene ether with a HLB of about 10 to about 12;
(f) at least one glycol in a quantity sufficient to prevent formation of salicylic acid crystals; and
(g) optionally, allantoin in an effective quantity.

### Claim 25 (depends on 24)

The skin care composition of claim 24, wherein the at least one glycol is selected from the group consisting of propylene glycol, ethoxydiglycol, and a mixture thereof.

### Claim 26 (depends on 24)

The skin care composition of claim 24, wherein the first nonionic polyoxyethylene ether is ceteareth-25.

### Claim 27 (depends on 24)

The skin care composition of claim 24, wherein the second nonionic polyoxyethylene ether is ceteareth-6 with stearyl alcohol.

### Claim 28 (depends on 24)

The skin care composition of claim 24, wherein the composition further comprises dimethicone.

### Claim 29 (depends on 24)

The skin care composition of claim 24, wherein the composition further comprises at least one of a plant extract and a herbal extract.

### Claim 30 (depends on 24)

The skin care composition of claim 24, wherein the composition further comprises a long-chain fatty acid ester of glycerol selected from the group consisting of glyceryl stearate, glyceryl palmitate, and glyceryl arachidate.

### Claim 31 (depends on 24)

The skin care composition of claim 24, wherein the composition further comprises caprylic/capric triglycerides.

### Claim 32 (depends on 24)

The skin care composition of claim 24, wherein the composition further comprises a preservative component.

### Claim 33 (depends on 32)

The composition of claim 32, wherein the preservative component further comprises at least one preservative selected from the group consisting of propylparaben, methylparaben, and 2-methyl-4-isothiazolin-3-one.

### Claim 34 (depends on 24)

The skin care composition of claim 24, wherein the composition further comprises an antioxidant component.

### Claim 35 (depends on 34)

The skin care composition of claim 34, wherein the antioxidant component comprises at least one antioxidant selected from the group consisting of butylated hydroxytoluene, butylated hydroxyanisole, and a complex comprising propyl gallate, propylene glycol, and citric acid.

### Claim 36 (depends on 24)

The skin care composition of claim 24, wherein the composition further comprises a chelator component.

### Claim 37 (depends on 36)

The skin care composition of claim 36, wherein the chelator component is tetrasodium ethylenediaminetetraacetic acid.

### Claim 38 (depends on 24)

The skin care composition of claim 24, wherein the composition further comprises a lipid-soluble long-chain alcohol component.

### Claim 39 (depends on 38)

The skin care composition of claim 38, wherein the lipid-soluble long-chain alcohol component comprises at least one lipid-soluble long-chain alcohol selected from the group consisting of stearyl alcohol and cetyl alcohol.

### Claim 40 (depends on 24)

The skin care composition of claim 24, wherein the composition further comprises a hydrophilic carbohydrate-containing polymer in an effective quantity.

### Claim 41 (depends on 40)

The skin care composition of claim 40, wherein the hydrophilic carbohydrate-containing polymer is selected from the group consisting of hydroxypropyl methylcellulose, hydroxyethyl ethylcellulose, methylcellulose, ethylcellulose, acacia gum, tragacanth gum, locust bean gum, guar gum, gum arabic, xanthan gum, and agarose.

### Claim 42 (depends on 24)

The skin care composition of claim 24, wherein the composition further comprises a quaternary ammonium-containing polymer in an effective quantity.

### Claim 43 (depends on 42)

The skin care composition of claim 42, wherein the quaternary ammonium-containing polymer is polyquaternium-10.

### Claim 44

A skin care composition comprising an oil-in-water emulsion, comprising:
(a) from about 40.0% to about 70.0% of water;
(b) from about 15.0% to about 25.0% of propylene glycol;
(c) from about 0.05% to about 0.20% of tetrasodium ethylenediaminetetraacetic acid;
(d) from about 1.50% to about 4.00% of ceteareth-25;
(e) from about 3.00% to about 10.00% of lanolin oil;
(f) from about 1.00% to about 4.00% of caprylic/capric triglycerides;
(g) from about 0.50% to about 3.00% of dimethicone;
(h) from about 3.00% to about 7.00% of cetyl alcohol;
(i) from about 2.00% to about 5.00% of stearyl alcohol;
(j) from about 1.00% to about 3.00% of glyceryl stearate;
(k) from about 2.00% to about 4.00% of ceteareth-6 with stearyl alcohol;
(l) from about 1.80% to about 3.00% of salicylic acid;
(m) from about 0.05% to about 2.0% of butylated hydroxytoluene;
(n) from about 0.005% to about 0.50% of a complex comprising Vitamin A and Vitamin D3;
(o) from about 0.10% to about 0.50% of methylparaben;
(p) from about 0.05% to about 0.50% of propylparaben;
(q) from about 0.01 % to about 0.08% of 2-methyl-4-isothiazolin-3-one;
(r) from about 0.10% to about 0.50% of fragrance;
(s) optionally, from about 0.025% to about 0.80% of at least one of a plant and a herbal extract; and
(t) optionally, from about 0.01% to about 1.5% of allantoin.

### Claim 45 (depends on 44)

A method for treating a dermatological or systemic inflammatory condition, comprising the step of applying the skin care composition of claim 44 to the skin of a patient in a therapeutically effective quantity.

### Claim 46 (depends on 45)

The method of claim 45, wherein the dermatological or systemic inflammatory condition is selected from the group consisting of psoriasis, seborrheic dermatitis and dandruff.

### Claim 47 (depends on 45)

The method of claim 45, further comprising the step of administering at least one additional topically or systemically administered agent for the treatment of psoriasis.

### Claim 48

A skin care composition comprising an oil-in-water emulsion comprising:
(a) water;
(b) a hydroxy acid in an effective quantity, the hydroxy acid being selected from the group consisting of α-hydroxy acids, β-hydroxy acids, and multi-hydroxy acids;
(c) lanolin oil in an effective quantity;
(d) a complex comprising Vitamin A and Vitamin D3 in an effective quantity;
(e) an emulsifier component in a quantity sufficient to effectively emulsify oil and water phases, the emulsifier component comprising:
(i) a first nonionic polyoxyethylene ether with a HLB of about 15 to about 17; and
(ii) a second nonionic polyoxyethylene ether with a HLB of about 10 to about 12;
(f) a glycol in a quantity sufficient to prevent formation of crystals of the hydroxy acid; and
(g) optionally, allantoin in an effective quantity.

### Claim 49 (depends on 48)

The skin care composition of claim 48, wherein the glycol is selected from the group consisting of propylene glycol, ethoxydiglycol, and a mixture thereof.

### Claim 50 (depends on 48)

The skin care composition of claim 48, wherein the composition further comprises a hydrophilic carbohydrate-containing polymer in an effective quantity.

### Claim 51 (depends on 50)

The skin care composition of claim 50, wherein the hydrophilic carbohydrate containing polymer is selected from the group consisting of hydroxypropyl methylcellulose, hydroxyethyl ethylcellulose, methylcellulose, ethylcellulose, acacia gum, tragacanth gum, locust bean gum, guar gum, gum arabic, xanthan gum, and agarose.

### Claim 52 (depends on 48)

The skin care composition of claim 48, wherein the composition further comprises a quaternary ammonium-containing polymer in an effective quantity.

### Claim 53 (depends on 52)

The skin care composition of claim 52, wherein the quaternary ammonium-containing polymer is polyquaternium-10.

### Claim 54 (depends on 48)

A method for treating a dermatological or systemic inflammatory condition comprising the step of applying the skin care composition of claim 48 to the skin of a patient in a therapeutically effective quantity.

### Claim 55 (depends on 54)

The method of claim 54, wherein the dermatological or systemic inflammatory condition is selected from the group consisting of psoriasis, seborrheic dermatitis and dandruff.

### Claim 56 (depends on 54)

The method of claim 54, further comprising the step of administering at least one additional topically or systemically administered agent for the treatment of psoriasis.

### Claim 57

A skin care composition comprising an oil-in-water emulsion, comprising:
(a) from about 40.0% to about 70.0% of water;
(b) from about 15.0% to about 30.0% of propylene glycol;
(c) from about 0.05% to about 0.20% of tetrasodium ethylenediaminetetraacetic acid;
(d) from about 1.50% to about 4.00% of ceteareth-25;
(e) from about 0.05% to about 0.30% of hydroxypropyl methylcellulose;
(f) from about 3.00% to about 10.0% of lanolin oil;
(g) from about 1.00% to about 4.00% of caprylic/capric triglycerides;
(h) from about 0.50% to about 3.00% of dimethicone;
(i) from about 3.00% to about 7.00% of cetyl alcohol;
(j) from about 2.00% to about 5.00% of stearyl alcohol;
(k) from about 2.00% to about 5.00% of ceteareth-6 with stearyl alcohol;
(l) from about 1.00% to about 4.00% of glyceryl stearate;
(m) from about 1.80% to about 3.00% of salicylic acid;
(n) from about 0.05% to about 2.00% of butylated hydroxytoluene;
(o) from about 0.005% to about 0.50% of a complex comprising Vitamin A and Vitamin D3;
(p) from about 0.10% to about 0.50% of methylparaben;
(q) from about 0.05% to about 0.50% of propylparaben;
(r) from about 0.01% to about 0.06% of 2-methyl-4-isothiazolin-3-one;
(s) from about 0.10% to about 0.50% of fragrance;
(t) optionally, from about 0.025% to about 0.50% of at least one plant or herbal extract; and
(u) optionally, from about 0.01% to about 1.5% of allantoin.

### Claim 58 (depends on 57)

The skin care composition of claim 57, wherein the composition further comprises from about 0.05% to about 0.30% of polyquaternium-10.

### Claim 59 (depends on 57)

A method for treating a dermatological or systemic inflammatory condition, comprising the step of applying the skin care composition of claim 57 to the skin of a patient in a therapeutically effective quantity.

### Claim 60 (depends on 59)

The method of claim 59, wherein the dermatological or systemic inflammatory condition is selected from the group consisting of psoriasis, seborrheic dermatitis and dandruff.

### Claim 61 (depends on 59)

The method of claim 59, further comprising the step of administering at least one additional topically or systemically administered agent for the treatment of psoriasis.

### Claim 62

A skin care composition, comprising:
(a) a shell comprising agar or gelatin;
(b) a solution of salicylic acid dissolved in at least one glycol, the solution being encapsulated in the shell; and
(c) a carrier for the shell, the carrier being in the form of a cream, gel, or ointment, the shell being broken to release the solution of salicylic acid when the composition is applied to the skin of a user.

### Claim 63 (depends on 62)

The skin care composition of claim 62, wherein the shell is agar.

### Claim 64 (depends on 62)

The skin care composition of claim 62, wherein the shell is gelatin.

### Claim 65 (depends on 62)

The skin care composition of claim 62, wherein the carrier is in the form of a cream.

### Claim 66 (depends on 65)

The skin care composition of claim 65, wherein the cream is an oil-in-water emulsion.

### Claim 67 (depends on 66)

The skin care composition of claim 66, wherein the oil-in-water emulsion further comprises a complex comprising Vitamin A and Vitamin D3 and lanolin oil.

### Claim 68 (depends on 62)

The skin care composition of claim 62, wherein the carrier is in the form of an ointment.

### Claim 69 (depends on 62)

The skin care composition of claim 62, wherein the carrier is in the form of a gel.

### Claim 70 (depends on 62)

The skin care composition of claim 62, wherein the carrier comprises about 70% by weight of the composition and the shell and encapsulated solution of salicylic acid comprise about 30% by weight of the composition.

### Claim 71 (depends on 65)

The skin care composition of claim 65 wherein the glycol is selected from the group consisting of propylene glycol, ethoxydiglycol, and a mixture thereof.