Vaccine comprising a polysaccharide antigen - carrier protein conjugate and free carrier protein
AssigneeSmithKline Beecham Biologicals s.a.
InventorsMoncef Mohamed Slaoui, Pierre Hauser
Life of this patent
Estimating the term…
Abstract
The present invention relates to combination vaccines comprising a conjugated polysaccharide antigen linked to a carrier protein, and wherein the carrier protein is also present as a free antigen in the vaccine composition, characterised in that the ratio of polysaccharide to protein is from 1:0:3 to 1:2. In particular, the vaccine composition of the present invention relates to a multivalent vaccine, that is a vaccine for the amelioration or treatment of more than one disease state. The present invention also relates to the production and use of such a vaccine in medicine.
Claims13
1 A combined vaccine comprising a polysaccharide antigen conjugated to a carrier protein, and wherein the carrier protein is also present as free antigen characterised in that the ratio of polysaccharide to carrier protein in the conjugate is from 1:0.3 to 1:2.
2 A combined vaccine as claimed in claim 1 wherein the carrier protein is a Diphtheria or Tetanus antigen.
3 A combined vaccine as claimed in claim 1 or 2 wherein the ratio of polysaccharide:
- carrier protein is from 1:0.5:1:1.5.
4 A combined vaccine as claimed in claim 1 wherein the polysaccharide component is derived from Heamophilus influenzae b (Hib) or Streptococcus pneumonia, or Neisseria meningitis A, B, or C.
5 A combined vaccine as claimed in claim 4, further comprising antigens protective against Diphtheria, Tetanus, and pertussis infection.
6 A combined vaccine as claimed in claim 4 or claim 5 further comprising an antigen against hepatitis B virus.
7 A combined vaccine as claimed in any one of claims 4 to 6 further comprising an antigen against hepatitis A virus.
8 A combined vaccine as claimed in any one of claims 4 to 7 further comprising an antigen providing immunity against polio
9 A combined vaccine composition according to any one of claims 4 to 8 comprising an antigen providing immunity to Streptococcus pneumoniae and Haemophilus influenzae B.
10 A combined vaccine according to any one of clams 4 to 9 additionally comprising a suitable adjuvant.
11 A vaccine as hereinbefore claimed for use in medicine.
12 A method of treating a human susceptible to or suffering from an infectious disease, comprising administering an effective amount of a vaccine as claimed in claims 1 to 10
13 A polysaccharide antigen conjugated to a carrier protein wherein the ratio of polysaccharide to carrier is from 1:0:3 to 1:2.