Recombinant yellow fever virus and methods of use thereof
AssigneeThe Regents of the University of California
InventorsRaul Andino-Pavlovsky, Andres McAllister-Moreno
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Abstract
The present invention provides recombinant yellow fever viruses (YFV), particularly live attenuated recombinant YFV, which comprise exogenous ( i.e., non-YFV) nucleotide sequences which encode exogenous (i.e., non-YFV) amino acid sequences. These recombinant YFV viruses comprise an exogenous nucleic acid. Infection of a host cell with a recombinant YFV provides for expression of the exogenous nucleic acid in a host cell and production of an antigenic polypeptide encoded by the exogenous nucleic acid. Such recombinant YFV are useful in eliciting an immune response to the exogenous polypeptide.
Claims27
An isolated recombinant yellow fever virus comprising an exogenous nucleic acid sequence encoding an exogenous polypeptide, wherein infection of a host with the recombinant virus provides for expression of the exogenous polypeptide by the host cell and induction of an immune response in a host.
An isolated recombinant yellow fever virus comprising a sequence encoding a recombinant polyprotein precursor, the polyprotein precursor comprising an exogenous nucleic acids sequence encoding an exogenous polypeptide.
Dependencies are inferred from the claim text.