Streptococcal streptolysin S vaccines
AssigneeThe University of Tennessee Research Corporation
InventorJames B. Dale
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Abstract
Provided are streptolysin S (SLS) polypeptides, peptides, and variants thereof, antibodies directed thereto, and isolated nucleic acids encoding such proteins. In one embodiment, a method is provided wherein a synthetic peptide of SLS is used to elicit an immune response specific for SLS in a subject to treat or prevent a streptococcal infection. In other embodiments, antibodies that neutralize the hemolytic activity of the SLS toxin may be used as a vaccinating agent.
Claims10
A composition, comprising a pharmaceutically acceptable carrier and a peptide immunogen for eliciting an immune response in a subject consisting of an amino acid sequence with at least 80% amino acid identity to SEQ ID NO:6 and having at least one streptolysin S epitope.
Dependencies are inferred from the claim text.