Virulence genes, proteins, and their use
OwnerSteven Neville Chatfieldinventor
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Abstract
A series of genes from Salmonella typhimurium are shown to encode products which are implicated in virulence. The identification of these genes threfore allows attenuated microorganisms to be produced. Furthermore, the genes or their encoded products can be used in the manufacture of vaccines for therapeutic application.
Claims21
A peptide encoded by an operon including any of the nucleotide sequences identified herein as SEQ ID NOS. 1, 4, 6, 8, 11, 13, 15, 17, 19, 21, 23 and 25, of S. typhimurium, or a related molecule having at least 40% sequence similarity or identity at the peptide or nucleotide level in a Gram-negative bacterium, or a functional fragment thereof, for therapeutic or diagnostic use.
A polynucleotide encoding a peptide according to any preceding claim, for therapeutic or diagnostic use.
Dependencies are inferred from the claim text.