Multiple antigen glycopeptide carbohydrate vaccine comprising the same and use thereof
AssigneeInstitut Pasteur
InventorsSYLVIE BAY, DANIELE CANTACUZENE, CLAUDE LECLERC, RICHARD LO-MAN, SOPHIE VICHER-GUERRE
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Abstract
A carbohydrate peptide conjugate comprising: a carrier comprising a dendrimeric poly-Lysine enabling multiple epitopes to be covalently attached thereto, at least one peptide comprising one T epitope or several identical or different T epitopes, at least one carbohydrate moiety, or a derivative thereof, containing B epitope, provided it is not a sialoside, or several identical or different epitopes. Use of this conjugate for inducing immune response.
Claims42
A carbohydrate peptide conjugate comprising:
- a carrier comprising a dendrimeric poly-Lysine enabling multiple epitopes to be covalently attached thereto,
- at least one peptide comprising one T epitope or several identical or different T epitopes,
- at least one carbohydrate moiety, or a derivative thereof, containing B epitope, provided it is not a sialoside, or several identical or different epitopes.
A carbohydrate peptide conjugate comprising:
- at least one peptide comprising one T epitope, or several identical or different T epitopes, and
- at least one carbohydrate moiety, or a derivative thereof, containing B epitope, provided it is not sialoside, or several identical of different epitopes.
A linear carbohydrate peptide conjugate comprising:
- at least one peptide comprising one T-epitope, or several identical or different T-epitopes, and
- at least one carbohydrate moiety, or a derivative thereof, containing a B-epitope, provided it is not a sialoside.
A carbohydrate peptide conjugate comprising:
- at least one peptide comprising one T epitope or several identical or different T epitopes, wherein at least one T epitope consists of a cytotoxic T cell (CTL) epitope.
An immunogenic composition of Tn molecules capable of enhancing the immune response after coupling said Tn molecule or Tn derivatives on a carrier consisting of a linear peptide or of a dendrimeric peptide or of a protein.
Immunogenic composition of Tn molecules capable of enhancing the immune response after coupling the said Tn or Tn derivatives on a carrier consisting in a linear peptide or a dendrimeric peptide or a protein.
Dependencies are inferred from the claim text.