Recombinant antibodies, and compositions and methods for making and using the same
AssigneeThomas Jefferson University
InventorsDouglas Craig Hooper, Bernhard Dietzschold
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Abstract
Recombinant antibodies are disclosed. The nucleic acid and encoded amino acid sequences of the heavy and light chain immunoglobulins of human monoclonal rabies virus neutralizing antibodies, and their use, are described.
Claims23
An isolated nucleic acid molecule comprising one or more nucleic acid sequence that encodes a heave chain and a light chain amino acid sequence, wherein said heavy chain and light chain amino acid sequences comprise a monoclonal rabies virus neutralizing antibody that specifically binds to a rabies virus protein.
An isolated nucleic acid molecule comprising one or more nucleic acid sequences that encode an amino acid selected from the group consisting of:
- SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14 and SEQ ID NO:16.
A fused gene encoding a chimeric immunoglobulin light chain, comprising:
- a) a first DNA sequence encoding an immunoglobulin light chain variable region of a monoclonal rabies virus neutralizing antibody produced by a heterhybridoma cell line;
- and
- b) a second DNA sequence encoding a human light chain constant region.
A fused gene encoding a chimeric immunoglobulin heavy chain, comprising:
- a) a first DNA sequence encoding an immunoglobulin heavy chain variable region of a monoclonal rabies virus neutralizing antibody produced by a heterhybridoma cell line;
- and
- b) a second DNA sequence encoding a human heavy chain constant region.
A recombinant antibody comprising a constant region of Mab 57 linked to a non-MAb 57 variable region.
Dependencies are inferred from the claim text.