Human amine transporter antibodies
AssigneeHuman Genome Sciences, Inc.
InventorsYi Li, Liang Cao, Craig A. Rosen
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Abstract
A Human amine transporter polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for detecting agonists and antagonists to such polypeptide and the use of agonists and antagonists for treating diseases related to the underexpression and over-expression of the Human amine transporter of the present invention. Also disclosed are methods for detecting mutations in the nucleic acid sequence encoding the polypeptide and for detecting altered levels of the soluble form of the polypeptide.
Claims20
An isolated polynucleotide selected from the group consisting of:
- (a) a polynucleotide encoding a polypeptide having the deduced amino acid sequence of SEQ ID NO. 2 and fragments, analogs or derivatives of said polypeptide;
- and
- (b) a polynucleotide encoding a polypeptide having the amino acid sequence encoded by the cDNA contained in ATCC Deposit No. 75980 and fragments, analogs or derivatives of said polypeptide.
A polypeptide selected from the group consisting of (i) a polypeptide having the deduced amino acid sequence of SEQ ID NO. 2 and fragments, analogs or derivatives thereof and (ii) a polypeptide encoded by the cDNA of ATCC Deposit No. 75980 and fragments, analogs or derivatives of said polypeptide.
A diagnostic process comprising:
- analyzing for the presence of the polypeptide of claim 22 in a sample derived from a host.
Dependencies are inferred from the claim text.