Methods for inhibiting brain tumor growth
AssigneeChildren's Hospital Los Angeles
InventorWalter E. Laug
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Abstract
The present invention describes methods for inhibition of tumor growth in the brain, using antagonists of integrins such as αvβ3 and αvβ5. Antagonists of the present invention can inhibit angiogenesis in brain tumor tissue. They can also inhibit vitronectin and tenascin-mediated cell adhesion and migration in brain tumor cells. They can further induce direct brain tumor cell death.
Claims5
A method of inhibiting tumor growth in the brain of a host, comprising administering to the host in need of such an inhibition a therapeutically effective amount of an integrin antagonist which is selected from the group consisting of an antibody against αvβ3, an antibody against αvβ5 and a combination of antibodies respectively against αvβ3 and αvβ5.
Dependencies are inferred from the claim text.